Journal «MEDICINA» 1/2019

The article analyzes the results of the implementation of the program «Development of pharmaceutical and medical industry» for 2013-2020 concerning the range of portfolios of domestic manufacturers, and the introduction of reference drugs to the Russian market. Replenishment of anatomical and therapeutic groups, as well as the relationship between the state requests for drug provision and drugs introduced in the state register of medicines are studied.

Key words: The introduction of new drugs, the reference of the medicines, development strategy

A severe case of corneal damage in patient with thyroid eye disease (TED) is presented. Surgical interventions and medication treatment performed on different disease stages are described. Complex treatment resulted in long-term stabilization and remission of TED. Brief review of literature deals with the problems of etiology, pathogenesis, risk factors and treatment of keratopathy associated with thyroid eye diseases. Treatment of corneal damage in patients with TED may be different and often complex, taking into consideration many factors. The choice of treatment depends on severity of corneal damage and orbital inflammation activity. Surgical treatment may include orbital decompression, lagophthalmos and eyelid retraction correction, corneal and squint surgery.

Key words: thyroid eye disease, corneal ulcer, dry eye syndrome, eyelid retraction, lagophthalmos, orbital decompression, pulse therapy, tarsorhaphy

The article discusses the inaccuracies made in some Russian publications when quoting a German-language paper presenting the results of a two-year observational study of the tolerability of enteric-coated acetylsalicylic acid.

Key words: acetylsalicylic acid, enteric-coated form, tolerability, observational study, validity, translation equivalence

Purpose: to evaluate significance of calculation errors of recognition and reconstruction of the cornea shape by analyzing of optical cuts images as independent diagnostic characteristic of keratokonus. Material and methods: In research series images of transverse optical cuts of the cornea of patients with I-IV stage keratokonus (24 patients, 24 eyes – 6 cases of each stage) and patients with regular corneal astigmatism as a control group (6 patients, 6 eyes) were included. In floating window for each image local curvature of corneal surface was calculated and its error numerically characterized. For evaluation of correlation between average error of calculation the radius of curvature of the anterior corneal surface with different stages of keratokonus each optical cut of the cornea was divided into 5 broad areas. In each area pairwise comparison of the calculation error of curvature radius for I and II stage of keratokonus as well as for control group using criteria of Mann-Whitney was done. Results: It was revealed that in control group average calculation error of the radius of curvature of the anterior corneal surface significantly differs (p<0,001) from such in groups with I and II stages of keratokonus. In control group average calculation error was near to 0,5 mm while in groups with I and II stages of keratokonus it was in 0,33-0,38 mm interval. Conclusion: evaluation of calculation error of the curvature radius of the anterior corneal surface can se used for creation of highly sensitive detectors of early keratokonus as independent diagnostic characteristic.

Key words: keratokonus, keratotopography, image recognition

In recent years, the countries of Southeast Asia became popular destinations among Russian tourists, including residents of Yakutia. The article describes a clinical case of Dengue fever in the Republic of Sakha (Yakutia) in a woman who was vacationing in Vietnam. The disease presented in the classical form, the outcome of the disease is favorable.

Key words: fever of unknown etiology, Dengue fever, imported infection

Basing on the analysis of international experience of interaction between the state and business in the field of public health, the authors have developed a classification of types of public-private partnership in healthcare. The first results of such cooperation in domestic healthcare are also presented.

Key words: healthcare, organization, public-private partnership, concession, outsourcing, outstaffing, leasing, healthcare legislation, medical law

In the present work, the morphological features of chronic polyposis rhinosinusitis in the tissues of the polyposis-altered mucosa of the nasal cavity are investigated. Morphological differences in the polyposis-altered mucosa of the nasal cavity have been established, which can be divided into several types. Each type of HPRS has its own characteristics, there are polyps with minimal vascularization or complete absence of blood vessels and numerous polymorphic-cellular infiltrates as well as disturbances in the interaction of factors inhibiting the pathological process, inflammatory cells (lymphocytes, granulocytes, mast cells, monocytes), which together with neuropeptides have an effect on the mucosa of the nasal cavity.

Key words: chronic polypous rhinosinusitis (HPRS), neuropeptides, hematoxylin and eosin, methylene green

We examined 212 healthy man with standard veloergometry test with gradual elevation of power in sitting and prone positions. Electrocardiogram, blood pressure, heart rate was registered. Tetrapolar rheography was used for estimate blood minute volume, heart strike volume, brain blood flow. Tissue conductivity was used for skin blood flow testing. Data were analyzed with coordination for I and III type of blood circulation. It was shown that there are clear changes between hemodynamic reactivity in sitting and prone positions. These changes were dependent on duration of physical exercises and illustrated by prolongation of the period of cardiovascular activation in recovery time. We fixed that longest period of this increase was registered for blood flow in brain and, especially, in skin. These tendencies may be associated with hemodynamic debt and demonstrate adaptation to physical exercises and restorative potential.

Key words: veloergometry, adaptation, physical exercises, anthropology, hemodynamics type

In experiments on rats, the effect of valprazolamide, a new antiepileptic agent from the group of amide derivatives of valproic acid, on the brain content of neuroactive amino acids (GABA, glycine, glutamic and aspartic acids) was studied. Detection of amino acids was performed by gas chromatography-mass spectrometry. It was shown that a single intraperitoneal injection of valprazolamide (100 mg / kg) increases the level of GABA and the amide form of glutamic acid, reduces the levels of asparagine, glutamic and aspartic acids in the rat brain.

Key words: valproates, antiepileptics, γ-aminobutyric acid, glycine, aspartic acid, glutamic acid

Ischemic stroke is the most common severe pathology among all the forms of cerebrovascular diseases. Nowadays the problem of pathogenetic therapy is relevant because of the high lethality and persistent disability of patients who have suffered from stroke. The aim of the study is to analyze the activation of internal genetically determined compensatory adaptive protective mechanisms which have been developed during the evolution progress and to use it as a pathogenic method of treating for the ischemic insult. The article provides analysis of national and foreign scientific reports from 2000 to 2017, determining the experimental and clinical studies of ischemic preconditioning. The possibility of its application in clinical practice is considered, the data on the effectiveness of endogenous protective mechanisms and neuroprotection are given, the conclusion about the relevance and scientific and practical significance of studies devoted to the phenomenon of preconditioning is made.

Key words: ischemic preconditioning, ischemic insult, ischemic tolerance, neuroprotection