Authors
Pavlush D. G.
Assistant, Chair for Histology, Embryology and Cytology1
Matveeva N. U.
Doctor of Medicine, Head, Chair for Histology, Embryology and Cytology1
Dyuizen I. V.
Corresponding Member of the Russian Academy of Sciences, Doctor of Medicine, Professor, Leading Researcher2
1 - Pañifiñ State Medical University, Vladivostok, Russia
2 - National Scientific Center of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
Corresponding Author
Pavlush Dmitry Georgievich; e-mail: pavlush.dmitrij@yandex.ru
Conflict of interest
None declared.
Funding
The study had no sponsorship.
Abstract
In the present work, the morphological features of chronic polyposis rhinosinusitis in the tissues of the polyposis-altered mucosa of the nasal cavity are investigated. Morphological differences in the polyposis-altered mucosa of the nasal cavity have been established, which can be divided into several types. Each type of HPRS has its own characteristics, there are polyps with minimal vascularization or complete absence of blood vessels and numerous polymorphic-cellular infiltrates as well as disturbances in the interaction of factors inhibiting the pathological process, inflammatory cells (lymphocytes, granulocytes, mast cells, monocytes), which together with neuropeptides have an effect on the mucosa of the nasal cavity.
Key words
chronic polypous rhinosinusitis (HPRS), neuropeptides, hematoxylin and eosin, methylene green
DOI
References
1. Beloshangin A.S. Variabel'nost' otvetnoj reakcii slizistoj obolochki nosa v zavisimosti ot provodimoj terapii pri polipoznom rinosinusite. [The variability of the response of the nasal mucosa depending on the therapy used for polyposis rhinosinusitis]. Rossijskaja otorinolaringologija [Russian Otorhinolaryngology] 2012; (6): 12-15.
2. Gilifanov E.A., Nevzorova V.A., Artjushkin S.A., Pavlush D.G. Kliniko-funkcional'naja harakteristika organov rechi i sluha u pacientov so stabil'nym techeniem hronicheskoj bolezn'ju legkih. [Clinical and functional characteristics of the organs of speech and hearing in patients with a stable course of chronic lung disease] Tihookeanskij medicinskij zhurnal [Pacific Medical Journal] 2014; (1): 45-47.
3. Dajhes N.A., Rjazancev S.V Polipoznye rinosinusity: jetiologija, patogenez, klinika i sovremennye metody lechenija. [Polyposis rhinosinusitis: etiology, pathogenesis, clinic and modern methods of treatment] Metod. Rekomendacii [Methodical recommendations]. St. Petersburg, 2014.
4. Zavadskij A.V., Zavadskij N.V. Citologija polipoza nosa i ee otnoshenie k patogenezu zabolevanija. [Cytology of the polyposis of the nose and its relation to the pathogenesis of the disease] Vestnik ushnyh, nosovyh i gorlovyh boleznej [Bulletin of the ear, nose and throat diseases] 2011; (1): 8-17.
5. Lepejko Ju.B, Nevzorova V.A., Gilifanov E.A., Pavlush D.G., Djujzen I.V. Izmenenie aktivnosti nejrokininovoj sistemy v slizistoj obolochke verhnih dyhatel'nyh putej krys pri modelirovanii tabakokurenija. [Changes in the activity of the neurokinin system in the mucous membrane of the upper respiratory tract of rats during the modeling of tobacco smoking]. Sibirskij nauchno-medicinskij zhurnal [Siberian Scientific Medical Journal] 2015; 35 (1): 19-27.
6. Pavlush D.G., Djujzen I.V. Analiz sovremennyh predstavlenij ob jetiopatogeneze polipoznogo rinosinusita. [Analysis of modern ideas about the etiopathogenesis of polypous rhinosinusitis]. Zhurnal Rossijskaja otorinolaringologija [Journal of Russian Otorhinolaryngology] 2016. 85(6): 95-102.
7. Pavlush D.G., Pavlush E.N., Matveeva N.Ju., Kalinichenko S.G., Djujzen I.V. Hronicheskij polipoznyj rinosinusit: jetiopatogeneticheskie mehanizmy ego vozniknovenija. [Chronic polyposis rhinosinusitis: etiopathogenetic mechanisms of its occurrence] Medicina 2018; (2): 69-78. doi:10.29234/2308-9113-2018-6-2-69-78.
8. Frendî M., Hàkansson K., Schwer S., Ravn Andreas T., Meteran H., et al. Exhaled and nasal nitric oxide in chronic rhinosinusitis patients with nasal polyps in primary care. Christian von Buchwald Rhinology 2018; 56: 59-64.
9. Kule Z.G., Habesoglu T.E., Somay A., Deveci H. S., Kule M., Gursel A.O. Histopathological Characteristics of Nasal Polyps in Smokers and Non-Smokers. The Journal of Craniofacial Surgery 2014; 25(3): 946-949.
10. Malekzadeh S., McGuire John F. The New Histologic Classification of Chronic Rhinosinusitis. Current Allergy and Asthma Reports 2003; (3): 221-226.
11. Nassenstein C., Braun A., Erpenbeck V.J., Lommatzsch M., Schmidt S., Krug N., et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med. 2003; 198: 67-455.
12. Shin J. M., Byun J. Y., Baek B. J., Lee J. Y. Cellular proliferation and angiogenesis in nasal polyps of young adult and geriatric patients. International Forum of Allergy & Rhinology 2015; 5(6): 541-546.
13. Tecimer S. Hancer, Kasapoglu F., Demir U. L., Ozmen O. A., Coskun H., Basut O. Correlation between clinical findings and eosinophil/neutrophil ratio in patients with nasal polyps. Eur Arch Otorhinolaryngol 2015; 272: 915-921.