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Use of Certain Calculated Hematological Parameters for the Diagnosis of Iron Deficiency Conditions in Children
Moshev A. V., Sychik E. V.
Iron deficiency conditions have many dangerous consequences, especially in childhood. The purpose of the article is to assess the diagnostic significance of some new calculated hematological parameters (low hemoglobin density) in the diagnosis of abovementioned conditions. The study was carried out on biological material from patients undergoing examination at the Rostov-on-Don Regional Clinical and Diagnostic Centre using standard hematological, biochemical and immunological techniques. The results obtained indicate the high diagnostic value of the indicator.
¹ 2, 2024, pp. 18-24
Validation of the Developed Method for the Determination of Carbamazepine in Blood Serum and Urine by High-Performance Liquid Chromatography with Diode-Matrix Detection Using Absolute Calibration
Khabieva N. A., Lyust E. N., Timerzyanov M. I.
For patients undergoing carbamazepine treatment, measuring its concentration in serum and urine may be appropriate to guide treatment. Objective. To validate the developed technique for the quantitative determination of carbamazepine in blood serum and urine. Materials and methods. In the work, biological fluids (blood serum and urine) were used as research objects. Quantitative determination of carbamazepine was carried out in the concentration range from 0,50 to 50,0 mcg/ml on a high-performance liquid chromatograph with diode-matrix detection (Agilent Technologies 1200) by absolute calibration method. To assess linearity, calibration graphs were constructed and the concentrations of the model mixtures were recalculated. The correctness and precision of the developed methodology was determined on the basis of sample analysis data. Results of the study and their discussion. The calibration dependences for blood serum and urine in the range of carbamazepine concentrations of 0,5 – 50,0 mcg/ml are linear. Reverse recalculation of concentrations according to the calibration schedule showed that the deviations of carbamazepine concentrations from the actual values did not exceed 15%. The limit of quantification was 0,5 mcg/ml. At validation of the method, the calculated values of the relative standard deviation do not exceed 6%, relative error – 10,2%. Specificity of the method in relation to carbamazepine was confirmed by the absence of peaks interfering with the determination of chromatograms relative to «blank» samples. Conclusion. The obtained results showed that the method of determination is sensitive, accurate, provides analytical range of measurement from 0,5 to 50,0 mcg/ml with satisfactory expressiveness of work. The technique provides a practical solution for therapeutic monitoring of carbamazepine content, determination of its concentration in forensic chemical practice.
¹ 2, 2024, pp. 8-17
Changes in Macular Pigment Optical Density on the Background of Various Tamponade of the Vitreal Cavity in Proliferative Diabetic Retinopathy Surgery
Chuprov A. D., Kalanov M. R., Kim V. L., Firsov A. S.
Purpose. To determine dynamic changes of macular pigment optical density against the background of vitreal cavity tamponade with gas-air mixture and silicone oil during vitreoretinal intervention for proliferative diabetic retinopathy. Material and methods. 82 patients (82 eyes) with proliferative diabetic retinopathy were included in the study. The patients were divided into 2 groups: the first group consisted of 38 patients (38 eyes), who underwent vitrectomy with gas-air tamponade of vitreal cavity (16% hexafluoroethane C2F6, Acreole (ARCAD)), second group – 44 patients (44 eyes) with similar scope of surgery and silicone oil tamponade of vitreal cavity (5700 cSt, Oxane 10ml Syringe (Bausch&Lomb)). Control examinations with determination of macular pigment optical density were performed before treatment, 1, 3 and 6 months after vitreoretinal interventions. The observation period was 6 months. Results. In 1 month after vitreoretinal intervention in the first group of patients there was a significant increase in the optical density of macular pigment in 1.1 times, in the second group – in 1.26 times, respectively (p < 0.01 in comparison with the data before treatment). After 3 months, there was an increase of this index by 1.07 times in the first group, with its decrease by 1.02 times in patients of the 2nd group (p <0.01 compared with data 1 month after surgery). In 6 months after surgical treatment, the average macular pigment optical density increased 1.5 times in first group (p <0.01 compared with data before surgery) and was 1.09 times higher compared with the results obtained in the second study group (p<0.01). This parameter also significantly increased in second group of patients by 1.43 times (p <0.01 to the data before surgery). Conclusion. After vitreoretinal intervention, in all cases there was a significant increase average index of macular pigment optical density, regardless of the used tamponade of the vitreal cavity. However, in the group with gas-air tamponade, this parameter was significantly higher in comparison with the data obtained in the group with silicone oil tamponade, and after its removal.
¹ 2, 2024, pp. 1-7
Assessment of the Impact of Religiosity on Mental Health
Bobyk O. A.
Due to the fact that modern scientific publications describe the different impact of religiosity on mental health, it seems relevant to conduct a scientific study on the comparative analysis of the impact of religion on mentally healthy people and persons with mental and behavioral disorders. Materials and methods: A questionnaire and a survey of 1,038 adult residents (510 patients with mental and behavioral disorders and 528 healthy individuals) permanently residing in Lugansk city was carried out on a voluntary basis. The questionnaire included a total of 67 questions and consisted of several sections, one of which (section VI) was questions concerning religiosity (faith in God, visiting religious temples, observing religious holidays, following Christian commandments). After the questionnaire, a separate clinical interview was conducted with patients suffering from mental and behavioral disorders who believe in God. Calculation of the specific weight of individuals according to the respective options for answering the questions was carried out. Results: it was found that in the group of patients with mental and behavioral disorders, there were significantly more persons who convincingly believe in God and frequently use prayer compared to mentally healthy people. Moreover, it was proved that religiosity has a positive effect on the mental state of patients. Preventive measures are recommended. 
¹ 1, 2024, pp. 118-125
Autologous Conditioned Serum in the Treatment of Patients with Orthopedic Diseases: Literature Review
Radygina L. V.
Treatment of orthopedic diseases is a pressing problem. Autologous conditioned serum is used in the treatment of osteoarthritis and exhibits a pronounced analgesic effect and improves joint function without significant side effects, even in cases resistant to other treatments. Autologous conditioned serum is also successfully used for meniscus pathology, tendon diseases, and osteochondrosis. Treatment with autologous conditioned serum is not only an effective method, but is also economically affordable.
¹ 1, 2024, pp. 109-117
Modern Possibilities of Correction of Sexual Dysfunction in Women with Neurological Diseases. A Review.
Mirkhamidova N. A., Usmankhodjaeva A. A.
The purpose of the study is to analyze research publications on sexual dysfunction, modern possibilities of diagnosis and treatment of this condition in women with neurological diseases. Material and methods. The search for literary sources was carried out in the electronic databases PubMed Central, MEDLINE, Science Direct, Cochrane Library in the period from 2000 to 2023. Conclusions. Sexual dysfunction (SD) is a fairly common problem affecting on average about 60% of female patients suffering from various neurological diseases. The presence of SD significantly impairs physical, psychological and social parameters of women's health. The number of studies dealing with the problem of SD is quite limited. It should be noted that the development of differentiated comprehensive rehabilitation programs for patients with SD is a qualitatively new approach and is potentially effective in the management of SD. However, there is currently insufficient data for the application of complex methods of recovery and treatment of SD, which implies further study of the effectiveness of various methods of correction of SD in clinical trials.
¹ 1, 2024, pp. 88-108
Main Pathologic Effects of Exposure to Highly Dispersed E-Cigarette Aerosol on Lung Cells and Respiratory Epithelium: Literature Review
Sinyakin I. A., Shestakova M. A., Beshlyaga O. Y., Batalova T. A.
Objective. To determine the pathologic role of highly dispersed e-cigarette aerosol on lung cells, respiratory epithelium, and the immune system. Results. A systematic analysis of scientific literature in the databases: PubMed, ResearchGate, Medscape, and Cochrane Library was performed. The search was conducted using the following keywords: e-cigarette, vape, juul, lung, airway, respiratory, respiratory, cough, methacholine, nasal, alveoli, immune, bronchial, tracheal, bronchoalveolar, nicotine, propylene glycol, vegetable glycerol, macrophages, epithelium, spirometry and SPF1. Based on the literature review, the following conclusion was reached: studies show measurable adverse biological effects on the bronchopulmonary apparatus in humans, animals, and in vitro. The pathologic effects of e-cigarettes have similarities to the effects of tobacco smoke on the pulmonary parenchyma. Conclusion. Analysis of the literature makes it possible to come to the conclusion that current knowledge of these pathologic effects is insufficient to determine whether exposure to e-cigarettes is less pathologic for the respiratory system than exposure to combustible tobacco products.
¹ 1, 2024, pp. 72-87
Management of Individual Risks by Patient in the Process of Interaction with The Healthcare System
Gelman V. Ya.
Due to the increasing degree of patients' participation in the treatment process, there is a need to realize the possible risks of decisions and take responsibility for them. The paper investigates the issues of individual risk management by the patient in the process of his interaction with the health care system. The methodological basis of the study was the analysis of scientific publications and generalized practical experience. The main stages of the treatment process have been consecutively considered. Possible risks are identified and qualitatively assessed, ways to reduce them are proposed. The complexity and diversity of risk management tasks facing the patient in case of his active participation in the treatment process are shown.
¹ 1, 2024, pp. 59-71
Clinical Cases
Clinical case of lung gangrene and ARDS after SARS-CoV-2 infection in a patient with chronic obstructive pulmonary disease
Alpidovskaya O. V.
COVID-19 is characterized by an unpredictable course, comorbidity, and high mortality in some patients. The article describes a case of the development of viral-bacterial pneumonia caused by SARS-CoV-2 and Fusobacteria, complicated by the development of gangrene of the lower lobe of the right lung with areas of decay. Case description. The patient was admitted for inpatient treatment, brought in by an ambulance team for emergency indications, complaining of pain when coughing, shortness of breath, body temperature increase up to 38.50C. Computed tomography of the chest: signs of viral-bacterial pneumonia. Infiltration in the region of the lower lobe of the right lung with melting lung tissue was determined. The diagnosis of COVID-19 was confirmed by PCR examination of nasopharyngeal swab. Diagnosis: New coronavirus infection COVID-19, severe course. Complications of the main disease: Bilateral viral-bacterial pneumonia. Gangrenous abscess of the left lung. On the background of the started treatment, a lethal outcome occurred. Autopsy revealed signs of viral-bacterial pneumonia and a decaying cavity with purulent contents, diffuse destructive changes with hemorrhages. Conclusion. The patient died as a result of viral-bacterial pneumonia, complicated by the development of gangrene of the lower lobe of the right lung with areas of decay and abscess formation and acute respiratory failure.
¹ 1, 2024, pp. 53-58
Infectious Diseases in Patients with Diabetes Mellitus: Literature Review
Skryabina A. A., Golenok E. S., Sobh M. M.
Diabetes mellitus is associated with increased susceptibility to infectious diseases. This is due to the fact that uncontrolled hyperglycemia is accompanied by impaired innate and adaptive immune response, micro- and macroangiopathies, neuropathy, and decreased urine antibacterial activity. Furthermore, complications of diabetes mellitus such as neuropathy and peripheral vascular disease can lead to skin ulceration with secondary bacterial infections. Bacteria can invade any organ of the human body, with the most common foci of infection in diabetes mellitus being the urinary tract, respiratory tract, skin, and soft tissues. Some infectious diseases are specific to patients with diabetes mellitus, such as malignant external otitis media, foot infections, and nasopharyngeal mucormycosis. Infectious processes may be the first manifestations of diabetes mellitus or provoking factors for inherent complications such as diabetic ketoacidosis and hypoglycemia. Glucose control can be an alternative tool in infection control not only in patients with diabetes mellitus. In addition, controlling hyperglycemia offers the potential to improve the outcome of some infectious diseases.
¹ 1, 2024, pp. 37-52