Markers of endothelial dysfunction in athletes with mitral valve prolapse

Vasilenko V. S.
MD, Professor, The Head of Hospital Therapy Department, Saint-Petersburg State Pediatric Medical University, E-mail vasilenkovladi@yandex.ru

Shapovalova A. B.
PhD, Associate professor, Hospital Therapy Department, Saint-Petersburg State Pediatric Medical University, E-mail annashapovalova@yandex.ru

Kul'chitskaya J. K.
PhD, The Lesgaft National State University of Physical Education, Sports and Health, St.-Petersburg, E-mail elizavetakulchickaya@mail.ru

Connective tissue dysplasia of the heart is the frequent manifestation of connective tissue disturbance. To clarify the etiopathogenic features of the heart connective tissue dysplasia in sportsmen investigation of endothelial markers (d-dimer, C-protein, von Willebrand’s factor and antithrombine III) and damage factors (low density lipoprotein, very low density lipoproteins, homocystein, cytokines IL-4, TNF-α, IL-8) the study in 16 female athletes with mitral prolapse I and II degrees was undertaken. It was detected that endothelial dysfunction in athletes with prolapse of the mitral valve was associated with high levels of D-dimer, reduction of von Willebrand’s factor activity and low antitrombine III. Also high activity of antiendothelial factors such as low and high density lipoproteins, homocysteine, IL-8 compared with the athletes without mitral valve prolapse was determined.

mitral valve prolapse, sportsmen, еndothelial dysfunction

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