Authors
Kochetova O. V.
PhD (Biology), Senior Researcher1
Avzaletdinova D. S.
MD, PhD, Assistant Professor, Chair for Endocrinology2
Korytina G. F.
Doctor of Biology, Professor, Chief Researcher1
Morugova T. V.
Doctor of Medicine, Professor, Head, Chair for Endocrinology2
Boboedova O. V.
Resident Doctor, Chair for Endocrinology2
1 - Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation
2 - Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of Healthcare Ministry of the Russian Federation, Ufa, Russian Federation
Corresponding Author
Avzaletdinova Diana; e-mail: hyppocrat@mail.ru.
Conflict of interest
None declared.
Funding
The study was supported by the Russian Science Foundation (No. 22-25-00010).
Abstract
Type 2 diabetes mellitus (T2D) is a complex chronic disease resulting from a lot of factors, including insulin resistance. One of the causes of the insulin resistance is the presence of chronic inflammation. This study aimed to analyze polymorphisms of genes of pro-inflammatory cytokines and their receptors (the gene coding tumor necrosis factor receptor superfamily member 1B TNFRSF1B, the genes coding A and B subunits of interleukin 12 IL12A, IL12B) and C-reactive protein (CRP) with T2D in Tatars. The single nucleotide polymorphism (SNP) rs568408 in IL12A (PFDR=0.00005, OR=5.28) was significantly associated with type 2 diabetes. Regression analysis revealed that rs3212227 in IL12Â was associated with the glycated hemoglobin HbA1c level and fasting blood glucose (Ð=0.0017 and Ð=0.03, respectively).
Key words
type 2 diabetes mellitus, inflammation, C-reactive protein, pro-inflammatory cytokines
DOI
References
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