Photodynamic Therapy in the Treatment of Choroidal Melanoma. Review

Boiko E. V.
Doctor of Medicine, Professor, Director¹; Head, Chair for Ophtalmology²; Professor, Chair for Ophtalmology³

Panova I. E.
Doctor of Medicine, Professor, Deputy Director for Science¹

Petrosyan Yu. M.
Laboratory Assistant, Scientific and Educational Department¹; Resident, Chair for Ophtalmology²

Samkovich E. V.
MD, PhD, Ophtalmologist¹

1 - Saint-Petersburg Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Saint-Petersburg, Russian Federation
2 - I.I. Mechnikov North-Western State Medical University, Saint-Petersburg, Russian Federation
3 - S.M. Kirov Military Medical Academy, Saint-Petersburg, Russian Federation

Petrosyan Yurij M.; e-mail: petrosyan.yurij@yandex.ru.

None declared.

The study had no sponsorship.

Choroidal melanoma is one of the most malignant tumors of the organ of vision, the development of which is associated with the risk of metastasis and the possibility of death, which indicates the relevance of the search and application of effective methods of treatment of this pathology. To date, in the treatment of choroidal melanoma, preference is given to organ-preserving methods aimed at achieving local control over the tumor. One of the promising organ-preserving techniques is photodynamic therapy, which is a treatment method based on the ability of a photosensitizer to absorb light, receive energy and interact with chemical substances, with the further development of toxic photodynamic reactions in target tissues, the occurrence of which is possible with the simultaneous presence of three components: a photosensitizer, light and oxygen. In our country, there is a number of studies devoted to the treatment of choroidal melanoma with PDT, basically presenting experimental research, pilot studies and demonstrating clinical cases. The purpose of this review is to summarize data on photodynamic therapy and the use of this technique in the treatment of choroidal melanoma.

choroidal melanoma, photodynamic therapy, uveal melanoma, photosensitizers, ophthalmooncology, treatment of choroidal melanoma

10.29234/2308-9113-2022-10-2-73-92

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