Prospects for the Use of Cetylpyridinium Chloride in Modern Medical Practice (Literature Review)

Nozhkina N. N.
Senior Lecturer, Chair for Pharmacy and Chemistry, Faculty of Pharmacy¹

Abdukadyrova A. R.
Student, Faculty of Pharmacy¹

Nozhina Е. А.
Student, Faculty of Pharmacy¹

Dvorskaya O. N.
Doctor of Pharmacy, Assistant Professor, Head, Chair for Pharmacy and Chemistry, Faculty of Pharmacy¹

1 - South-Ural State Medical University, Chelyabinsk, Russian Federation

Dvorskaya Oksana; e-mail: dvoksnik@gmail.com.

The authors declare no conflict of interest.

The study had no sponsorship.

Currently, the search for antiseptic agents is being actively conducted, including in connection with the spread of the SARS-CoV-2 virus. One of the promising antiseptics is cetylpyridinium chloride (CPC). The published analysis of the Pubmed database provides a general idea of the use of CPC in modern medical practice as an antibacterial, antifungal and antiviral agent in the composition of various medicines and products for dentistry.

antiseptics, cetylpyridinium chloride, antimicrobial activity, antiviral effect

10.29234/2308-9113-2022-10-2-56-64

1. Vidal. Directory of medicines. Available at: https://www.vidal.ru/drugs/molecule/204 Accessed: 04.03.2022.

2. Golub V.A. Aseptika i antiseptika. [Aseptics and antiseptics.] Volgograd: VolgSMU, 2019. (In Russ.)

3. Lysak V.V. Mikrobiologiya. [Microbiology.] Minsk: BGU, 2007. (In Russ.)

4. Alvarez D.M., Duarte L.F., Corrales N., Smith P.C., González P.A. Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts. Antiviral Research. 2020; 179 :104818, doi: 10.1016/j.antiviral.2020.104818

5. Carrouel F., Gonçalves L.S., Conte M.P., Campus G., Fisher J, et al. Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2. J Dent Res. 2021;100(2):124-132, doi: 10.1177/0022034520967933

6. Ehrhardt A., Mandelli J.Z., Bérgamo V., Lopes W., Donato R.K., Zanette R.A., Fuentefria A.M. Glass ionomer cement modified by a imidazolium salt: adding antifungal properties to a biomaterial. Braz J Microbiol. 2021; 52(3):1347-1352, doi: 10.1007/s42770-021-00511-5

7. Funk B., Kirmayer D., Sahar-Heft S., Gati I., Friedman M., Steinberg D. Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro. BMC Oral Health 2019;19(1):190, doi: 10.1186/s12903-019-0879-1

8. Haraszthy V.I., Sreenivasan P.K. Microbiological and clinical effects of an oral hygiene regimen. Contemp Clin Trials Commun. 2017; 8: 85-89, doi: 10.1016/j.conctc.2017.08.010

9. Kang J.H., Jang Y.J., Kim D.J., Park J.W. Antimicrobial effectiveness of cetylpyridinium chloride and zinc chloride-containing mouthrinses on bacteria of halitosis and peri-implant disease. Int J Oral Maxillofac Implants 2015;30(6):1341-7, doi: 10.11607/jomi.3824.

10. Mao X., Auer D.L. Buchalla W., Hiller K.A., Maisch T., Hellwig E., et al. 20. Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance. Antimicrob Agents Chemother. 2020; 64(8): e00576-20, doi: 10.1128/AAC.00576- 20

11. Mateos-Moreno M.V., Mira A., Ausina-Márquez V., Ferrer M.D. Oral antiseptics against coronavirus: in-vitro and clinical evidence. J Hosp Infect. 2021; 113: 30-43, doi: 10.1016/j.jhin.2021.04.004

12. Mukherjee P.K., Esper F., Buchheit K., Arters K., Adkins I., Ghannoum M.A., Salata R.A. Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections. BMC Infect Dis. 2017; 17(1): 74, doi: 10.1186/s12879-016-2177-8

13. Naoe T., Hasebe A., Horiuchi R., Makita Y., Okazaki Y. Yasuda K., et al. Development of tissue conditioner containing cetylpyridinium chloride montmorillonite as new antimicrobial agent: Pilot study on antimicrobial activity and biocompatibility. J Prosthodont Res. 2020; 64 (4):436-443, doi: 10.1016/j.jpor.2019.12.002

14. Paunovska M.L., Coleman N.J., Stevanovic M.M., Dimkov A.G., Gabric D., Gjorgievska E.S. Effects of Addition of Quaternary Ammonium Antimicrobial Compounds into Root Canal Sealers. Eur J Dent. 2019; 13(2): 243-247, doi: 10.1055/s-0039-1688524

15. Popkin D.L., Zilka S., Dimaano M., Fujioka H., Rackley C., Salata R., et al. Cetylpyridinium chloride (CPC) exhibits potent, rapid activity against influenza viruses in vitro and in vivo. Pathog Immun. 2017: 2(2): 252-269, doi: 10.20411/pai.v2i2.200

16. Seo H.W., Seo J.P., Cho Y., Ko E.et al. Cetylpyridinium chloride interaction with the hepatitis B virus core protein inhibits capsid assembly. Virus Research. 2019: 263: 102-111, doi: 10.1016/j.virusres.2019.01.004

17. Teng F., He T., Huang S., Bo C.P., Li Z., Chang J.L., Liu J.Q., Charbonneau D., et al. Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation. Int J Oral Sci. 2016;8(3):182-90, doi: 10.1038/ijos.2016.18

18. Vergara-Buenaventura A., Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. Br J Oral Maxillofac Surg. 2020; 58(8): 924-927, doi: 10.1016/j.bjoms.2020.08.016

19. Verma T., Sharma P., Kumar P., Tyagi K., Bhatnagar S., Raza M.. Evaluation of antimicrobial property of modified acrylic resin-containing cetylpyridinium chloride. J Orthod Sci. 2020; 9(1):1, doi: 10.4103/jos.JOS­_6­_19

20. Xiang J., Li H., Pan B., Chang J., He Y., He T., Strand R., Shi Y., Dong W. Penetration and bactericidal efficacy of two oral care products in an oral biofilm model. Am J Dent. 2018; 31(1): 53-60.