Authors
Synoda V. A.
Doctor of Medicine, Assistant Professor, Head, Chair for Hygiene and Ecology1
Zhmakin I. A.
MD, PhD, Assistant Professor, Head, Chair for Mobilization Training of Public Health and Disaster Medicine1
Kudrich L. A.
Doctor of Medicine, Professor, Chair for Mobilization Training of Public Health and Disaster Medicine1
Vasiliev P. V.
MD, PhD, Assistant Professor, Chair for Hygiene and Ecology1
Bakanov K. B.
MD, PhD, Assistant Professor, Chair for Mobilization Training of Public Health and Disaster Medicine1
Kuznetsova A. M.
Senior Lecturer, Chair for Mobilization Training of Public Health and Disaster Medicine1
1 - Tver State Medical University, Tver, Russia
Corresponding Author
Zhmakin Igor; e-mail: 4822konstom@mail.ru
Conflict of interest
None declared.
Funding
The study had no sponsorship.
Abstract
Background. The Russian and international community is concerned about the growing incidence of measles. This is typical for highly developed and developing countries and has an impact on the epidemic situation in Russia. Purpose of research: to study the main results of the activities carried out by the Rospotrebnadzor administration in the Tver region to improve the state of the environment and protect the population of the Tver region from measles infection. Material and methods. The results of implementation of measures to reduce the impact of risk factors of measles on the health of the population of the Tver region in 2017-2019 were analyzed. Analyzed indicators are: the incidence of measles per 100 thousand population; coverage of preventive vaccinations to prevent the spread of measles among controlled individuals (%); results of serological monitoring of the state of collective immunity against measles in indicator population groups by a passive hemagglutination reaction method with a protective titer of 1:10 or more (absolute number, %); comparative assessment of changes in indicators of the number of measles seronegative persons in indicator groups of the population (%). Results and discussion. A set of measures aimed at preventing the incidence of measles is being implemented in the Tver region. To do this, the population is immunized against measles every year. In 2017 38,881 people were vaccinated, in 2018 – 35,476 and in 2019 – 42,347 people. This led to the fact that in 2017 in the Tver region there were no cases of measles. In 2018 the incidence of measles was 0.23 per 100 thousand population (3 cases) and in 2019 – 0.86 per 100 thousand population (11 cases). All cases of measles were imported from foreign countries and various regions of Russia. The situation in the incidence of measles in the Tver region is much better than in the Russian Federation and the Central Federal District of Russia. This is facilitated by a consistently high vaccination coverage of adults and children. Vaccination coverage of children aged two years in 2019 amounted to 98.2%, at the age of 6 years – 94.4% and adults 18-35 years old – 99.7%. If during seromonitoring an increase in the specific gravity of seronegative persons was detected, then their vaccination was carried out as planned. Conclusion. The implementation on a regular basis by the Office of Rospotrebnadzor in the Tver region of a set of effective measures aimed at combating measles helps prevent the incidence of measles infection in the population of the Tver region.
Key words
habitat, measles, incidence, vaccination, collective immunity, serological monitoring
DOI
References
1. V rezul'tate vspleska zabolevaemosti kor'ju v mire umerlo 140 000 chelovek. Vsemirnaja organizacija zdravoohranenija. [As a result of the surge in measles cases, 140,000 people have died worldwide. World health organization]. 2020. Available at: https://www.who.int/ru/news-room/detail/05-12-2019-more-than-140-000-die-from-measles-as-cases-surge-worldwide Accessed: 07.08.2020. (In Russ.)
2. Gosudarstvennaja programma Tverskoj oblasti «Zdravoohranenie Tverskoj oblasti» na 2015-2020 gody. Prilozhenie k postanovleniju Pravitel'stva Tverskoj oblasti ot 14.10.2014 ¹511-pp. Ministerstvo zdravoohranenija Tverskoj oblasti. [State program of the Tver region «Health of the Tver region» for 2015-2020. Appendix to the decree of the government of the Tver region of 14.10.2014 No. 511-PP. Ministry of health of the Tver region]. Available at: https://xn--80aeelexi0a.xn--80aaccp4ajwpkgbl4lpb.xn--p1ai/np-baza/ Accessed: 07.08.2020. (In Russ.)
3. Gosudarstvennyj doklad «O sostojanii sanitarno-epidemiologicheskogo blagopoluchija naselenija v Tverskoj oblasti v 2017 godu». Upravlenie Rospotrebnadzora po Tverskoj oblasti. [State report «On the state of sanitary and epidemiological welfare of the population in the Tver region in 2017». Department of Rospotrebnadzor for the Tver region]. 2018. Available at: http://69.rospotrebnadzor.ru/documents/regional/page8/ Accessed: 07.08.2020. (In Russ.)
4. Gosudarstvennyj doklad «O sostojanii sanitarno-epidemiologicheskogo blagopoluchija naselenija v Tverskoj oblasti v 2018 godu». Upravlenie Rospotrebnadzora po Tverskoj oblasti. [State report «On the state of sanitary and epidemiological welfare of the population in the Tver region in 2018». Department of Rospotrebnadzor for the Tver region]. 2019. Available at: http://69.rospotrebnadzor.ru/documents/regional/page4/ Accessed: 07.08.2020. (In Russ.)
5. Gosudarstvennyj doklad «O sostojanii sanitarno-epidemiologicheskogo blagopoluchija naselenija v Tverskoj oblasti v 2019 godu». Upravlenie Rospotrebnadzora po Tverskoj oblasti. [State report «On the state of sanitary and epidemiological welfare of the population in the Tver region in 2019». Department of Rospotrebnadzor for the Tver region]. 2020. Available at: http://69.rospotrebnadzor.ru/s/69/files/documents/regional/gos_doklady/148222.pdf Accessed: 07.08.2020. (In Russ.)
6. Kor'. Vsemirnaja organizacija zdravoohranenija. [Measles. World health organization]. 2020. Available at: http://www.whogis.com/topics/measles/ru/ Accessed: 07.08.2020. (In Russ.)
7. MU 3.1.2943-11. Metodicheskie ukazanija «Organizacija i provedenie serologicheskogo monitoringa sostojanija kollektivnogo immuniteta k infekcijam, upravljaemym sredstvami specificheskoj profilaktiki (difterija, stolbnjak, kokljush, kor', krasnuha, epidemicheskij parotit, poliomielit, gepatit V)». Utverzhdeny 15.07.2011g. i vvedeny v dejstvie Glavnym gosudarstvennym sanitarnym vrachom RF. [MU 3.1.2943-11. Guidelines «Organization and conduct of serological monitoring of the state of collective immunity to infections managed by means of specific prevention (diphtheria, tetanus, whooping cough, measles, rubella, mumps, polio, hepatitis B)». Approved on 15.07.2011 and put into effect by the Chief state sanitary doctor of the Russian Federation]. Available at: http://docs.cntd.ru/document/1200088401 Accessed: 07.08.2020. (In Russ.)
8. Nozdracheva A.V., Semenenko T.A., Asatrjan M.N. i dr. Immunologicheskaja vospriimchivost' naselenija megapolisa k kori na etape ee eliminacii. [Immunological susceptibility of the megalopolis population to measles at the stage of its elimination]. Epidemiologija i vakcinoprofilaktika. [Epidemiology and vaccination] 2019; 18(2): 18-26. (In Russ.)
9. O situacii s zabolevaemost'ju kor'ju v Rossii i zarubezhnyh stranah. Rospotrebnadzor. [About the situation with the incidence of measles in Russia and foreign countries. Rospotrebnadzor]. 2019. Available at: https://www.rospotrebnadzor.ru/about/info/news/news_details.php?ELEMENT_ID=11283 Accessed: 07.08.2020. (In Russ.)
10. Platonova T.A., Golubkova A.A., Obabkov V.N. et al. Mnogofaktornoe imitacionnoe modelirovanie v prognoze zabolevaemosti kor'ju na blizhajshuju i otdalennuju perspektivu. [Multi-factor simulation in the forecast of measles incidence in the near and long term]. Epidemiologija i infekcionnye bolezni. [Epidemiology and infectious diseases] 2018; 23(5): 225-233. (In Russ.)
11. Pozdnjakov A.A., Chernjavskaja O.P. Projavlenija epidemicheskogo processa kori i krasnuhi na sovremennom etape. [Manifestations of the epidemic process of measles and rubella at the present stage]. Epidemiologija i vakcinoprofilaktika. [Epidemiology and vaccination] 2018; 17(5): 45-53. (In Russ.)
12. Ponezheva Zh.B., Arakeljan A.K., Kozlova M.S., Vdovina E.T. Kor' u vzroslyh. [Measles in adults]. Epidemiologija i infekcionnye bolezni. Aktual'nye voprosy. [Epidemiology and infectious diseases. Topical issues] 2018; 2: 50-55. (In Russ.)
13. Programma «Eliminacija kori i krasnuhi v Rossijskoj Federacii (2016-2020 gg.». Utverzhdena Rospotrebnadzorom 28.12.2015g. i Minzdravom Rossii 31.12.2015g. [The program «Elimination of measles and rubella in the Russian Federation (2016-2020)». Approved by Rospotrebnadzor on 28.12.2015 and the Ministry of health of Russia 31.12.2015]. 2016. Available at: http://www.consultant.ru/document/cons_doc_LAW_254035/ Accessed: 07.08.2020. (In Russ.)
14. Rusakov V.N., Monastyrskij M.V., Levshunov A.M. Vlijanie immunizacii protiv kori na mnogoletnjuju dinamiku zabolevaemosti kor'ju na territorii Zapadnogo administrativnogo okruga goroda Moskvy. [Influence of measles immunization on the long-term dynamics of measles incidence in the Western administrative district of Moscow]. Infekcija i immunitet. [Infection and immunity] 2017; S: 599. (In Russ.)
15. Smirnova G.I., Korsunskij A.A. Epidemiologija i profilaktika kori: aktual'nye problemy. [Epidemiology and prevention of measles: current issues]. Epidemiologija i infekcionnye bolezni. [Epidemiology and infectious diseases] 2019; 24(2): 52-60. (In Russ.)
16. SP 3.1.2952-11. «Ob utverzhdenii SP 3.1.2952-11 »Profilaktika kori, krasnuhi i epidemicheskogo parotita«». Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 28.07.2011 ¹108. [SP 3.1.2952-11. «On approval of SP 3.1.2952-11 »Prevention of measles, rubella and mumps«». Resolution of the Chief state sanitary doctor of the Russian Federation No. 108 dated 28.07.2011]. 2011. Available at: http://docs.cntd.ru/document/902292235 Accessed: 07.08.2020. (In Russ.)
17. Usacheva E.V., Silina E.A., Pahol'chuk T.N. i dr. Kor' – upravljaemaja infekcija! Nekotorye jepidemiologicheskie «paradigmy» kori v Zaporozhskoj oblasti. [Measles is a controlled infection! Some epidemiological «paradigms» of measles in the Zaporozhye region]. Sovremennaja pediatrija. [Modern Pediatrics] 2019; 1(97): 13-18. (In Russ.)
18. Junasova T.N., Gorenkov D.V., Rukavishnikov A.V. i dr. Analiz zabolevaemosti kor'ju v Rossii i problemy profilaktiki kori na etape eliminacii. [Analysis of measles incidence in Russia and problems of measles prevention at the elimination stage]. Biopreparaty. Profilaktika, diagnostika, lechenie. [Biologicals. Prevention, diagnosis, treatment] 2019; 19(3): 154-160. (In Russ.)
19. Avramovich E., Indenbaum V., Haber M. et al. Measles outbreak in a highly vaccinated population – Israel, July-August 2017. Morbidity and Mortality Weekly Report 2018; 67(42): 1186-1188.
20. Fraser B. Measles outbreak in the Americas. Lancet 2018; 392(10145): 373-373.
21. Godefroy R., Chaud P., Ninove L. et al. Measles outbreak in a French Roma community in the Provence – Alpes – Cote d'Azur region, France, May to July 2017. International Journal of Infectious Diseases 2018; 76: 97-101. Available at: https://doi.org/10.1016/j.ijid.2018.08.023 Accessed: 07.08.2020.
22. Goldani L.Z. Measles outbreak in Brazil. Brazilian Journal of Infectious Diseases 2018; 22(5): 359.
23. Holt E. 41000 measles cases in Europe since the beginning of 2018. Lancet (London, England) 2018; 392 (10149): 724.
24. Komabayashi K., Seto J., Tanaka S. et al. 2018. The largest measles outbreak, including 38 modified measles and 22 typical measles cases in its elimination era in Yamagata, Japan. Japanese Journal of Infectious Diseases 2017; 71(6): 413-418.
25. Laszlo O., Gabor G., Agnes R. et al. Epidemiological situation of measles in Romania, Italy, and Hungary: on what threats should we focus nowadays? Acta Microbiologica et Immunologica Hungarica 2018; 65(2): 127-134. Available at: https://doi.org/10.1556/030.65.2018.014 Accessed: 07.08.2020.
26. Leslie T.F., Delamater P.L., Yang Y.T. It could have been much worse: The Minnesota measles outbreak of 2017. Vaccine 2018; 36(14): 1808-1810.