Authors
Khasanova G. R.
MD, PhD, Professor, Head, Chair for Epidemiology and Evidence Based Medicine1
Àgliullin D. R.
Postgraduate Student, Chair for Epidemiology and Evidence Based Medicine1
Abdulaeva E. A.
PhD, Associate Professor, Head, Chair for Ophthalmology2
Kagirova L. R.
Epidemiologist3
1 - Kazan State Medical University, Kazan, Russia
2 - Kazan State Medical Academy – Branch Campus of the FSBEIFPE RMACPE MOH Russia, Kazan, Russia
3 - Central City Clinical Hospital ¹ 18 of Kazan, Kazan, Russia
Corresponding Author
Agliullin Damir; e-mail: dr.agliullin@gmail.com
Conflict of interest
None declared.
Funding
The study had no sponsorship.
Abstract
Aim of the study: Assessment of the influence of potential risk factors on the development of central serous chorioretinopathy in a large industrial city. Materials and Methods: Case-control study of persons aged 18 years and older. The study group included 100 patients with central serous chorioretinopathy, confirmed by optical coherence tomography, and controls – 100 patients without central serous chorioretinopathy. The groups are comparable in gender and age. Interviewing of patients was carried out according to the developed questionnaire, including 33 questions. One-way and multivariate analysis of the results using logistic regression was carried out. Statistical data processing was carried out using Microsoft Office Excel 2010, Jamovi programs, R – Studio statistical package, OpenEpi online calculators (http://www.openepi.com). Results: The following risk factors for CSC were identified: taking corticosteroid drugs in the last year – OR 13.5; 95% CI 3.4-53.2 and the presence of arterial hypertension – OR 8.3; 95% CI 1.3-54.1. Intake of antihypertensive drugs and psychotropic drugs from the group of anxiolytics were statistically significant factors in the «prevention» of the development of CSC (OR 0.1; 95% CI 0.02-0.9 and OR 0.01; 95% CI 0.0003− 0.5), respectively. The presence of myopia also proved to be a protective factor for CSC –OR 0.3; 95% CI 0.14-0.8. Conclusion: In a case-control study, significant risk factors for CSC for the population of a large industrial city were arterial hypertension and the use of corticosteroid drugs. The presence of myopia is associated with a lower incidence of CSC.
Key words
central serous chorioretinopathy, epidemiology, risk factors, case control, arterial hypertension, corticosteroids
DOI
References
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