Pathomorphology of granulomas of the tooth root in various times of the inflammation

Sirak S. V.
Doctor of Medicine, Professor, Head, Chair for Dentistry¹

Bykova N. I.
Ph.D., associate professor, Chair for Pediatric Dentistry, Orthodontics and maxillofacial surgery²

Laypanova F. M.
Postgraduate student, Chair for Dentistry¹

Shchetinin E. V.
Doctor of Medicine, Professor, Head, Chair for Pathophysiology¹

Vafiadi A. A.
Postgraduate student, Chair for Pathophysiology¹

1 - Stavropol State Medical University, Russia
2 - Kuban State Medical University, Krasnodar, Russia

Evgeny V. Shchetinin; e-mail: ev.cliph@rambler.ru

None declared.

The study had no sponsorship.

The article presents the results of study of pathomorphological features of the granulomas structure with acute and chronic inflammation. Studied were 112 granulomas, sampled after the removal of the teeth in individuals of different age groups, mainly up to 50 years (88,6%). In 95 granulomas neural elements were investigated, in 17 – a morphological and histochemical studies were performed. It is established that dystrophic processes in acute inflammation of the periapical tissue are characterized by a decrease in the content of glycogen, and pathological changes of the nervous elements of granulomas are concomitant with protein dystrophy and a violation of the tinctorial properties of axially-cylindrical part of the nerve fibers. Neural elements in the long-existing granulomas are characterized by severe degenerative and destructive processes as well as phenomena of reactive growth and hyperplasia of nerve fibers. The data obtained permit us to adjust both the tactic of surgical intervention and the tactics of active transapical therapy.

inflammation, granuloma, nerve fibers

10.29234/2308-9113-2018-6-3-96-106

1. Berezin K.A. Gistokhimicheskiye osobennosti razvitiya patologicheskogo protsessa pri khronicheskikh formakh periodontita [Histochemical features of the development of the pathological process in chronic forms of periodontitis] Parodontologiya [Periodontology] 2014; 19 (3): 63-67. (In Russ)

2. Berezin K.A., Grekov A.Ch., Zaripova E.M., Startseva E.Yu. Statisticheskiye aspekty izucheniya rasprostranennosti khronicheskogo apikal'nogo periodontita u vzroslogo naseleniya [Statistical aspects of studying the prevalence of chronic apical periodontitis in the adult population]. Sovremennie problem nauki i obrazovaniya [Modern problems of science and education] 2015; (2): 119. (In Russ)

3. Goldobin D.D., Loktionov A.L., Bystrova N.A. Immunnyye narusheniya na sistemnom i lokal'nom urovnyakh pri khronicheskom periodontite, vzaimosvyaz s oksidantnymi izmeneniyami [Immune disorders at the systemic and local levels with chronic periodontitis, the relationship with oxidative changes]. Immunologiya [Immunology] 2017; 38(1): 35-39. (In Russ)

4. Grechishnikov V.V. Klassifikatsiya simptomov sochetannykh porazheniy endodonto-periodontalnogo kompleksa i parodonta [Classification of symptoms of combined lesions of the endodonto-periodontal complex and periodontium]. Folia Otorhinolaryngologiae et Pathologiae Respiratoriae 2013; 19 (3): 63-67. (In Russ)

5. Iordanishvili A.K., Slugina A.G., Balin L.V., Serikov A.A. Vozrastnyye osobennosti rasprostranennosti khronicheskikh periapikal'nykh ochagov odontogennoy infektsii u vzroslykh lyudey [Age features of the prevalence of chronic periapical foci of odontogenic infection in adults]. Kurskii nauchno-prakticheskii vestnik «Chelovek i ego zdorovie» [Kursk scientific and practical bulletin «Man and his health»] 2015; 2: 23-28. (In Russ)

6. Kabak Yu.S., Kabak S.L., Anishchenko S.L. Gistomorfologiya khronicheskogo apikal'nogo periodontita [Histomorphology of chronic apical periodontitis]. Stomatologiya [Dentistry] 2008; 87(3): 13-18. (In Russ)

7. Kukushkin V.L., Smirnitskaya M.V., Kukushkina E.A., Nikulina V.Yu. Nekotoryye epidemiologicheskiye aspekty oslozhneniy kariyesa zubov [Some epidemiological aspects of complications of dental caries]. Endodontiya Today [Endodonty Today] 2014; (1): 3-5. (In Russ.)

8. Nacheva L.V., Tkachenko T.S. Funktsionalnaya morfologiya ksenoparazitarnogo bar'era kak adaptivnaya reaktsiya pri khronicheskom vospalenii raznoy etiologii [Functional morphology of xenoparasitic barrier as adaptive reaction in chronic inflammation of different etiology]. Medicina v Donbasse [Medicine in Donbass] 2010; 1: 3-8. (In Russ)

9. Sirak S.V., Bykova N.I., Shсhetinin E.V., Petrosyan G.G., Didenko N.N. Fermentativnyye zashchitnyye mekhanizmy parodonta pri eksperimental'nom vospalenii [Enzymatic protective mechanisms of periodontal disease with experimental inflammation]. Medicinskij vestnik Severnogo Kavkaza [Medical News of North Caucasus] 2014; 9(4): 349-351. https://doi.org/10.14300/mnnc.2014.09097 (In Russ)

10. Chibisova M.A., Zubareva A.A., Kholin A.V., Kaizerov E.V., Charishev R.H. Kliniko-rentgenologicheskiye osobennosti razlichnykh form khronicheskikh periodontitov [Clinical and rentgenological features of various forms of chronic periodontitis]. Institut stomatologii [Institute of Dentistry] 2016; (2): 38-43. (In Russ)

11. Hirsch V., Wolgin M., Mitronin A.V., Kielbassa A.M. Inflammatory cytokines in normal and irreversibly inflamed pulps: A systematic review. Archives of Oral Biology 2017; 82: 38-46. https://doi.org/10.1016/j.archoralbio.2017.05.008

12. Slots J. Periodontitis: facts, fallacies and the future. Periodontology 2000 2017; 75(1): 7-23. https://doi.org/10.1111/prd.12221