Modeling of oxidative and psychoemotional stress in rats with the effect of pyrimidine derivatives

Rozenfeld I. I.
MD PhD, Chair for Pathological Physiology Tver State Medical University, Tver, Russia.¹

Lobynceva E. A.
Student, Medical Faculty¹

1 - Tver State Medical University, Tver, Russia.

Rozenfeld Igor; e-mail: iiggo@mail.ru

None declared.

The study had no sponsorship.

In an experimental study, 60 animals were used. Depending on the amount of thiamine in the diet, the animals were divided into following 3 research groups (20 each): control group I – with a normal diet; group II – thiamine was completely absent in the diet, products containing vitamin B₁ were excluded; group III – in the diet, foods rich in vitamin B₁ predominated. To evaluate the results, artificial impact was applied by hot air flow with noise, an «open field» installation, an «elevated cross-shaped labyrinth» installation. In the course of the experiments, it was found that a decrease in daily thiamine negatively affects cognitive abilities, the resistance of the organism to a stress factor decreases.

oxidative stress, psychoemotional stress, pyrimidine derivatives, thiamine, vitamine B₁

10.29234/2308-9113-2018-6-2-94-105

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