Chronic polyposis rhinosinusitis: etiopathogenetic mechanisms of its occurrence

Pavlush D. G.
Postgraduate, Central Research Laboratory, Assistant, Chair for Histology, Embryology and Cytology¹

Pavlush E. N.
Therapist³

Matveeva N. U.
Doctor of Medicine, Head, Chair for Histology, Embryology and Cytology¹

Kalinichenko S. G.
Doctor of Medicine, Professor, Chair for Histology, Embryology and Cytology¹

Dyuizen I. V.
Corresponding Member of the Russian Academy of Sciences, Doctor of Medicine, Professor, Leading Researcher²

1 - Paсifiс State Medical University, Vladivostok, Russia
2 - National Scientific Center of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia.
3 - Primary Regional Clinical Hospital №1, Vladivostok, Russia

Pavlush Dmitry Georgievich; e-mail: pavlush.dmitrij@yandex.ru

None declared.

The study had no sponsorship.

In the present review, the main etiopathogenetic mechanisms of the development of chronic polypous rhinosinusitis (HPRS) are considered. The interrelationship of some neurotrophic factors and sensory neuropeptides capable of causing neurogenic inflammation is established. As a result, the amount and volume of the polypositively altered mucosa of the nasal cavity and upper respiratory tract is increased. The article gives a general idea of HPRS, its etiology, pathogenesis and the supporting factors. Data on ways of and methods of treatment of HPRS are also given.

chronic polypous rhinosinusitis (HPRS), neurotransmitters, sensory neuropeptides, neurotrophic factors, Vidic nerve

10.29234/2308-9113-2018-6-2-69-78

1. Zavadskij A.V., Zavadskij N.V. Citologija polipoza nosa i ee otnoshenie k patogenezu zabolevanija [Cytology of the polyposis of the nose and its relation to the pathogenesis of the disease]. Vestnik ushnyh, nosovyh i gorlovyh boleznej [Bulletin of the ear, nose and throat diseases] 2011; (1): 8-17. (In Russ.)

2. Lepejko Ju.B., Nevzorova V.A., Gilifanov E.A., Djujzen I.V., Pavlush D.G. Izmenenie aktivnosti nejrokininovoj sistemy v slizistoj obolochke verhnih dyhatel'nyh putej krys pri modelirovanii hronicheskogo tabakokurenija [Change in the activity of the neurokinin system in the mucous membrane of the upper respiratory tract of rats during the modeling of chronic smoking]. Sibirskij nauchnyj medicinskij zhurnal [Siberian Scientific Medical Journal] 2015; 35 (1): 19-27. (In Russ.)

3. Lopatin A.S., Gamov V.P. Ostryj i hronicheskij rinosinusit: jetiologija, patogenez, klinika, diagnostika i principy lechenija [Acute and chronic rhinosinusitis: etiology, pathogenesis, clinic, diagnosis and treatment principles]. Moscow: Prakticheskaja medicina, 2014. (In Russ.)

4. Pavlush D.G., Djujzen I.V. Analiz sovremennyh predstavlenij ob etiopatogeneze polipoznogo rinosinusita [Analysis of modern ideas about the etiopathogenesis of polypous rhinosinusitis]. Rossijskaja otorinolaringologija [Russian Otorhinolaryngology] 2016; (6): 95-102. (In Russ.)

5. Pavlush D.G., Djujzen I.V. Morfologicheskaja organizacija i kletochnyj profil v polipoznoj tkani polosti nosa. 5-ja mezhvuzovskoj nauchno-prakticheskoj konferencii molodyh uchjonyh (Tver', 23 nojabrja 2017 g.) [Morphological organization and cellular profile in the polypous tissue of the nasal cavity. 5-th Inter-University Scientific and Practical Conference of Young Scientists (Tver, November 23, 2017)]. Tver, 2017. p. 333-334. (In Russ.)

6. Soldatov I.B., Hrappo N.S., Shherbakov V.A. Variant klassifikacii polipoznogo sinusita [Optional classification of polyposis sinusitis]. Rossijskaja rinologija [Russian rhinology] 1997. (2): 16. (In Russ.)

7. Bateman Neil D., Fahy Colm. Nasal polyps: Still more questions than answers. The Journal of Laryngology & Otology 2003; (1): 1-9.

8. Baudoin T., Kalogjera L., Hat J.I. Capsaicin significantly reduces sinonasal polyps. Acta Otolaryngol 2000; 120 (2): 307-11.

9. Drake-Lee A.B. Nasal polyps. Hospital Med. 2004; 65: 264-267.

10. Fokkens W.J., Lund V.J., Mullol J., Bachert C., Alobid I., Baroody F. et al. Pocket Guide EPOS European Position Paper on Rhinosinusitus and Nasal Polyps 2012. Rhinol Suppl. 2012 Mar; (23): 1-298.

11. Jonathan R. N., Kim W. Ah-See. A review of nasal polyposis. Therapeutics and Clinical Risk Management 2008; 4(2): 507-512.

12. Malekzadeh Sonya, McGuire John F. The New Histologic Classification of Chronic Rhinosinusitis. Current Allergy and Asthma Reports 2003; (3): 221-226.

13. Mygind N., Dahl R., Bachert C. Nasal polyposis, eosinophils dominated inflammation and allergy. Thorax 2000; 55(2): 79-83.

14. Nassenstein C., Braun A., Erpenbeck V.J., Lommatzsch M., Schmidt S., Krug N., et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med. 2003; 198: 67-455.

15. Nockher W. A., Renz H. Neurotrophins in allergic diseases: From neuronal growth factors to intercellular signaling molecules. Allergy Clin Immunol 2006; 117: 583-589

16. Peth G., Braun A., Meents N., Kerzel S., Quarcoo D., Raap U., et al. Augmentation of allergic early-phase reaction by nerve growth factor. Am J Respir Crit Care Med. 2002; 166: 818-26.

17. Swoboda S., Thulesius H.L., Jessen M. Paradoxical increase in nasal airway resistance after topical nasal decongestion – does it really exist? A retro- and prospective study. Clin Otolaryngology 2016; 41(6): 689-693.

18. Vento S.L., Ertama L.O., Hytonen M.L., Wolff C.H., Malmberg C.H. Nasal polyposis: Clinical course during 20 years. Ann Allergy Asthma Immunol 2000; 85: 209-14.

19. Vergnolle N., Denadai-Souza A., Martin L., Vieira de Paula M.A., Werneck de Avellar M.C., Muscará M.N., Cenac N. A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. Br. J Pharmacol. 2010; (5): 1161-1173.

20. Woodhead C.J. Neuropeptides in nasal mucosa. Clin. Otolaryngol. 1994; 19: 277-286.

21. Zhang P.J., Weber R., Liang H.-H., Pasha T.L., LiVolsi V.A. Growth Factors and Receptors in Juvenile Nasopharyngeal Angiofibroma and Nasal Polyps. Arch Pathol Lab Med 2003; 127 (11): 1480-1484.