Experimental and clinical use of multipotent mesenchymal stem cells to stimulate articular cartilage regeneration

Novikov A. V.
Doctor of Medicine, Leading Researcher, Nizhny Novgorod Research Institute of Traumatology and Orthopedics of Public Health Ministry of Russian Federation. E-mail: novik2.55@inbox.ru

The article analyzes the data published in recent years concerning application of cell technologies in treatment of patients with arthronosos. Author examines the sources of multipotent cells, delivery methods and main pathological conditions they were used under. The conclusion is drawn on the absence of convincing data on advantages of a particular method of cell delivery to the affected area. To confirm the safety of this therapy longer observation periods are required. Issues concerning the best source of stromal cells, technique of their harvesting and processing, dosage, cell transport to the affected area, influence of various physical factors remain unsolved. The problem of explicit indications for the cell therapy use continues to be relevant.

multipotent mesenchymal stem cells (MMSC), cell technology, joint, articular cartilage

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