Authors
Bogomolova E. B.
junior researcher, Department of Reconstructive Surgery and Restorative Treatment1
Martusevich A. K.
Doct. Biol. Sci., Head, Laboratory of Medical Biophysics1
Klemenova I. A.
Doct. Med. Sci., Vice-director for Science and Innovations1
Yanin D. V.
researcher, Laboratory of Space Plasma2
Galka A. G.
junior researcher, Laboratory of Space Plasma2
1 - Privolzhsky Federal Medical Research Center, Nizhny Novgorod
2 - Federal Research Center «Institute of Applied Physics» of RAS, Nizhny Novgorod
Abstract
The aim of this review is to study feasibility of near-field resonance microwave tomography as a new diagnostic tool for estimation of pathological scars parameters. Data about modern classification, etiology, pathogenesis and formation stages of skin scars are systemized. Technologies of pathological scars study are discussed. Special features and advantages of near-field resonance microwave tomography for the stated application, based on understanding of method’s physical principles, are shown.
Key words
microwave probing, skin, wound, burn
References
1. Belousov, A. E. Ocherki plasticheskoj hirurgii. T. 1: Rubcy i ih korrekciya.[Studies on plastic surgery. Scars and their correction]. Vol. 1. St Petersburg: Komandor-SPB, 2005.
2. Guller, A. E., L. V. Shurova, and V. A. Menzul. «Vliyanie vozrasta pacienta na strukturu rubcov pri pogranichnyh dermal'nyh ozhogah [Influence of the patient's age on the structure of scars in border dermal burns].» Eksperimental'naya i klinicheskaya dermatokosmetologiya, no. 3 (2006): 6-14.
3. Edriss, Ahmed Samir, and V. Smrcka. «Therapy of keloid and hypertrophic scars: a review.» European Journal of Plastic Surgery 34, no. 6 (2011): 425-36. doi:10.1007/s00238-011-0602-1.
4. Monstrey, S., E. Middelkoop, and J. J. Vranckx. «Updated scar management practical guidelines: non-invasive and invasive measures.» J. Plast. Reconstr. Aesthet. Surg. 67, no. 8 (2014): 1017-025.
5. Taganov, A. V. Sovremennye tekhnologii v lechenii rubcovyh gipertrofij. Eksperimental'noe i kliniko-morfologicheskoe issledovanie: Avtoref. diss. na soiskanie uchenoj stepeni d. med. nauk.[Modern technologies in the treatment of cicatricial hypertrophy. Experimental and clinical morphological study. Abstract of Doctor of Medicine thesis], Moscow, 2010.
6. Shafranov, V. V., N. G. Korotkij, A. V. Taganov, and E. N. Borhunova. «Keloidnye i gipertroficheskie rubcy: kliniko-morfologicheskie paralleli. [Keloid and hypertrophic scars: clinical and morphological parallels].» Detskaya hirurgiya, no. 4 (1998): 30-34.
7. Belousov, A. E. Plasticheskaya rekonstruktivnaya i ehsteticheskaya hirurgiya. [Plastic reconstructive and aesthetic surgery]. St Petersburg, 1998.
8. Paramonov, B. A. Primenenie kosmeticheskogo sredstva Fermenkol dlya profilaktiki i korrekcii rubcov kozhi. Metodicheskie rekomendacii. [The use of the cosmetics Fermenkol for the prevention and correction of skin scars. Guidelines]. St Petersburg, 2005.
9. Yudenich, V. V., and V. M. Grishkevich. Rukovodstvo po reabilitacii obozhzhennyh. [Guide for the rehabilitation of burned]. Moscow: Medicina, 1986.
10. Reznikova, A. E. Kliniko-morfologicheskie osobennosti lecheniya i profilaktiki rubcov lica i shei u detej: Avtoref. dis. na soiskanie uchenoj stepeni kand. med. nauk. [Clinical and morphological features of treatment and prevention of face and neck scars in children: Abstract for PhD thesis]. Moscow, 1999.
11. Shekhter, A. B., and A. E. Guller. «Morfologicheskaya diagnostika rubcovyh tkanej i novaya kliniko-morfologicheskaya klassifikaciya rubcov kozhi cheloveka. [Morphological diagnosis of scar tissue and a new clinico-morphological classification of human skin scars].» Arhiv patologii 70, no. 2 (2008): 6-13.
12. Guller, A. E., L. V. Shurova, V. A. Menzul, and A. B. Shekhter. «O nekotoryh osobennostyah rubcevaniya pri operativnom lechenii glubokih ozhogov kozhi [On some features of scarring during surgical treatment of deep skin burns].» Eksperimental'naya i klinicheskaya dermatokosmetologiya, no. 6 (2006): 2-9.
13. Guller, A. E., and A. B. Shekhter. «Klinicheskij tip i gistologicheskaya struktura kozhnyh rubcov kak prognosticheskie faktory iskhoda lecheniya. [Clinical type and histological structure of cutaneous scars as prognostic factors of outcome of treatment].» Annaly plasticheskoj, rekonstruktivnoj i ehsteticheskoj hirurgii, no. 2 (2007): 19-31.
14. English, R. S., and P. D. Shenefelt. «Keloid and hypertrophic scars.» Dermatol. Surg.25, no. 8 (1999): 631.
15. Taganov, A. V. «Morfologicheskie otlichiya tkanej gipertroficheskih i keloidnyh rubcov. [Morphological differences of the tissues of hypertrophic and keloid scars].» In Aktual'nye voprosy dermatologii i venerologii. Sbornik trudov yubil. konf. [Topical issues of dermatology and venereology. Collected works of jubileum conference], 114-17. Moscow, 1997.
16. Pikuła, Michał, Maria E. Żebrowska, Loretta Pobłocka-Olech, Mirosława Krauze-Baranowska, Małgorzata Sznitowska, and Piotr Trzonkowski. «Effect of enoxaparin and onion extract on human skin fibroblast cell line – Therapeutic implications for the treatment of keloids.» Pharmaceutical Biology 52, no. 2 (2013): 262-67. doi:10.3109/13880209.2013.826246.
17. Al-Attar, Ali, Sarah Mess, John Michael Thomassen, C. Lisa Kauffman, and Steven P. Davison. «Keloid Pathogenesis and Treatment.» Plastic and Reconstructive Surgery 117, no. 1 (2006): 286-300. doi:10.1097/01.prs.0000195073.73580.46.
18. Brissett, Anthony E., and David A. Sherris. «Scar Contractures, Hypertrophic Scars, and Keloids.» Facial Plastic Surgery 17, no. 04 (2001): 263-72. doi:10.1055/s-2001-18827.
19. Filippova, O. V., and I. V. Krasnogorskij. «Strukturnye izmeneniya v rubcovoj tkani u detej na razlichnyh ehtapah sozrevaniya rubca i na fone kollagenoliticheskoj terapii. [Structural changes in scar tissue in children at different stages of rumen maturation and with collagenolytic therapy].» Klinicheskaya dermatologiya i venerologiya, no. 1 (2013): 22-30.
20. Alekseev, A. A., V. A. Lavrov, M. G. Lagvilava, and G. B. Yakovlev. «Profilaktika i lechenie posleozhogovyh rubcov gelem ”Kontraktubeks”. [Prophylaxis and treatment of post-burn scars with ”Kontraktubeks” gel].» In Konservativnoe lechenie rubcov: Sb. nauch. tr. [Conservative treatment of scars. Colected scientific works], 6-11. Moscow, 2000.
21. Burd, Andrew. «Keloid epidemiology: Population based studies needed.» Journal of Plastic, Reconstructive & Aesthetic Surgery 59, no. 1 (2006): 105. doi:10.1016/j.bjps.2005.07.012.
22. Marneros, Alexander G., James E.c. Norris, Shoji Watanabe, Ernst Reichenberger, and Bjorn R. Olsen. «Genome Scans Provide Evidence for Keloid Susceptibility Loci on Chromosomes 2q23 and 7p11.» Journal of Investigative Dermatology 122, no. 5 (2004): 1126-132. doi:10.1111/j.0022-202x.2004.22327.x.
23. Shih, Barbara, and Ardeshir Bayat. «Genetics of keloid scarring.» Archives of Dermatological Research 302, no. 5 (2010): 319-39. doi:10.1007/s00403-009-1014-y.
24. Marneros, Alexander G., James E. C. Norris, Bjorn R. Olsen, and Ernst Reichenberger. «Clinical Genetics of Familial Keloids.» Archives of Dermatology 137, no. 11 (2001). doi:10.1001/archderm.137.11.1429.
25. Bloom, D. «Heredity of keloids: Review of the literature and report of a family with multiple keloids in five generations.» NY State J. Med., no. 56 (1956): 511-19.
26. Cosman, B., G. F. Crikelair, D. M. C. Ju, J. C. Gaulin, and R. Lattes. «The Surgical Treatment Of Keloids.» Plastic and Reconstructive Surgery 27, no. 3 (1961): 335-58. doi:10.1097/00006534-196104000-00001.
27. Castagnoli, C., D. Peruccio, M. Stella, G. Magliacani, G. Mazzola, A. Amoroso, and P. Richiardi. «The HLA-DRβ16 allogenotype constitutes a risk factor for hypertrophic scarring.» Human Immunology 29, no. 3 (1990): 229-32. doi:10.1016/0198-8859(90)90117-8.
28. Thomas, Katherine, and Paul Critchley. «Management of scars.» Surgery (Oxford) 24, no. 1 (2006): 18-20. doi:10.1383/surg.2006.24.1.18.
29. Genderen, M. M Van. «Ocular features in Rubinstein-Taybi syndrome: investigation of 24 patients and review of the literature.» British Journal of Ophthalmology 84, no. 10 (2000): 1177-184. doi:10.1136/bjo.84.10.1177.
30. Goeminne, L. «A new inherited syndrome: congenital torticollis, multiple keloids, cryptorchidism and renal dysplasia.» Acta Genet. Med. Gemellol.17 (1968): 439-67.
31. Matsuda, Yukihisa, Ichiro Murano, Osamu Kondoh, Kiyosato Matsuo, and Tadashi Kajii. «Cardio-Facio-cutaneous (CFC) syndrome: Report of two patients without hyperkeratotic skin lesions.» American Journal of Medical Genetics 39, no. 2 (1991): 144-47. doi:10.1002/ajmg.1320390206.
32. Igarashi , A., K. Nashiro, and K. Kikuchi. «Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders.» J. Invest. Dermatol. 106, no. 4 (1996): 729-33.
33. Shimohashi, Naoya, Masayuki Furukawa, Hiroya Yamaguchi, Toshihiko Hashimoto, Fumio Umeda, and Hajime Nawata. «Ectodermal Dysplasia Syndrome in Siblings with True Keloids, Stenosis of the Esophagus after Operations for Congenital Achalasia and Renovascular Hypertension due to Stenosis of Renal Artery.» Internal Medicine 34, no. 5 (1995): 406-09. doi:10.2169/internalmedicine.34.406.
34. Karpf, A. J., E. London, and M. Rousso. «Syndactylism with keloid scar formation.» J. Foot. Ankle. Surg. 32, no. 5 (1993): 509-13.
35. Placik, O. J., and V. L. Lewis. «Immunologic associations of keloids.» Surg. Gynecol. Obstet. 175 (1992): 185.
36. Niessen, Frank B., Paul H. M. Spauwen, Joost Schalkwijk, and Moshe Kon. «On the Nature of Hypertrophic Scars and Keloids: A Review.» Plastic and Reconstructive Surgery 104, no. 5 (1999): 1435-458. doi:10.1097/00006534-199910000-00031.
37. Vladimirova, O. V. Kompleksnyj podhod k pervichnoj i vtorichnoj profilaktike posttravmaticheskih rubcov: Avtoref. diss. na soiskanie uchenoj stepeni kand. med. nauk. [Complex approach to primary and secondary prevention of post-traumatic scars: Abstract of PhD thesis] Stavropol', 2011.
38. Urioste, Sandy S., Kenneth A. Arndt, and Jeffrey S. Dover. «Keloids and hypertrophic scars: Review and treatment strategies.» Seminars in Cutaneous Medicine and Surgery18, no. 2 (1999): 159-71. doi:10.1016/s1085-5629(99)80040-6.
39. Bolhovitinova, L. A., and M. N. Pavlova. Keloidnye rubcy [Keloid scars]. Moscow: Medicina, 1977.
40. Akaishi, Satoshi, Rei Ogawa, and Hiko Hyakusoku. «Keloid and hypertrophic scar: Neurogenic inflammation hypotheses.» Medical Hypotheses 71, no. 1 (2008): 32-38. doi:10.1016/j.mehy.2008.01.032.
41. Slemp, A. E., and R. E. Kirschner. «Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management.» Curr. Opin. Pediatr.18 (2006): 396-402.
42. Del'vig, A. A. «Issledovanie metabolizma kollagena gipertroficheskih i keloidnyh rubcov. [Study of the metabolism of collagen hypertrophic and keloid scars].» Vestnik RAMN, no. 12 (1995): 41-45.
43. Vozdvizhenskij, S. I., and A. A. Del'vig. «Sravnitel'noe issledovanie kollagena gipertroficheskih i keloidnyh rubcov. [Comparative study of hypertrophic and keloid scars collagen].»Voprosy medicinskoj himii 42, no. 3 (1996): 240-45.
44. Meenakshi, J., V. Jayaraman, and K. M. Ramakrishnan. «Keloids and hypertrophic scars: a review.» Indian J Plast Surg. 38 (2005): 175-79.
45. Bettinger, D. A., D. R. Yager, R. F. Diegelmann, and I. K. Cohen. «The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis.» Plast. Reconstr. Surg. 98, no. 5 (1996): 827-33.
46. Berman, Brian, Martha H. Viera, Sadegh Amini, Ran Huo, and Isaac S. Jones. «Prevention and Management of Hypertrophic Scars and Keloids After Burns in Children.» Journal of Craniofacial Surgery 19, no. 4 (2008): 989-1006. doi:10.1097/scs.0b013e318175f3a7.
47. Verhaegen, P. D., P. P. Zuijlen, Van, and N. M. Pennings. «Differences in collagen architecture between keloid, hypertrophic scar, normotrophic scar, and normal skin: An objective histopathological analysis.» Wound Repair Regen.17, no. 5 (2009): 649-56.
48. Trykova, I.A. Ultrazvukovoe issledovanie v diagnostike i vybore taktiki lecheniya pacientov s rubcovymi deformaciyami pokrovnyh tkanej: Avtoref. dis. na soiskanie uchenoj stepeni kand. med. nauk. [Ultrasonic investigation in diagnosis and choice of tactics of treatment of patients with scar deformations of integumentary tissues: Abstract of PhD thesis], Moscow, 2013.
49. Thompson, L. D. «Skin keloid.» Ear Nose Throat J.83, no. 8 (2004): 519-24.
50. Oliver, Noelynn, Mary Babu, and Robert Diegelmann. «Fibronectin Gene Transcription Is Enhanced in Abnormal Wound Healing.» Journal of Investigative Dermatology 99, no. 5 (1992): 579-86. doi:10.1111/1523-1747.ep12667776.
51. Reznik, A.N. and Yurasova N.V. Blizhnepol'naya SVCH tomografiya biologicheskih sred. [Near-field microwave tomography of biological media] Zhurnal tekhnicheskoj fiziki 74, no.4 (2004): 108-16.
52. Kostrov, A. B., A. B. Strikovskij, and D. V. Yanin. «Issledovanie ehlektrodinamicheskih parametrov biologicheskih tkanej [Investigation of electrodynamic parameters of biological tissues].» Al'manah klinicheskoj mediciny, no. 17-2 (2008): 96-99.
53. Yanin, D. V., A. G. Galka, and A. I. Smirnov. «Neinvazivnaya diagnostika melanomy i drugih novoobrazovanij kozhi metodom rezonansnogo blizhnepol'nogo SVCH-zondirovaniya [Noninvasive diagnosis of melanoma and other skin lesions by resonance near-field microwave sounding].» Zhurnal radioehlektroniki, no. 1 (2015): 20.
54. Baloshin, Yu A., A. A. Sorokin, and A. N. Volchenko. «Elektrodinamicheskaya model' VCH-blizhnepol'nogo zondirovaniya fizicheskih ob'ektov [Electrodynamic model of high-frequency near-field sounding of physical objects].» Izvestiya VUZov. Priborostroenie, no. 12 (2011): 68-73.
55. Gajkovich, K. P. «Skaniruyushchaya blizhnepol'naya ehlektromagnitnaya tomografiya [Scanning near-field electromagnetic tomography].» Nano- i mikrosistemnaya tekhnika, no. 8 (2007): 50.
56. Panteleeva, G. A., Z. V. Davoyan, and D. V. Yanin. «Rezonansnaya blizhnepol'naya SVCH-diagnostika dermatozov s ladonno-podoshvennoj lokalizaciej. [Resonance near-field microwave diagnostics of dermatoses with palmar-plantar localization].» In 3 Kongress dermatovenerologov [3 rd Congress of Dermatovenerologists], 51. Proceedings. Kazan, 2009.
57. Arsen'ev, A. V., A. N. Volchenko, L. V. Lihachyova, and V. I. Pecherskij. «Primenenie metoda VCH-blizhnepol'nogo zondirovaniya v diagnostike bioob'ektov [The application of the HF-near-field sounding method in the diagnosis of bioobjects].» Nauchno-tekhnicheskij vestnik informacionnyh tekhnologij, mekhaniki i optiki, no. 2 (2011): 154-57.
58. Zagajnov, V. E., A. B. Kostrov, and A. B. Strikovskij. «Ispol'zovanie lokal'nogo vozdejstviya ehnergii SVCH dlya termicheskogo razrusheniya opuholej pecheni (v klinike) [The use of local effects of microwave energy for the thermal destruction of liver tumors (in clinical settings)].» Sovremennye tekhnologii v medicine, no. 1 (2011): 29-34.
59. Mironov , S. V., V. E. Zagajnov, and S. A. Vasenin. «Primenenie blizhnepol'nogo izmereniya ehlektrodinamicheskih parametrov dlya ehkspress-diagnostiki sostoyaniya pecheni [Application of near-field measurement of electrodynamic parameters for express diagnostics of liver condition].» Sovremennye tekhnologii v medicine1, no. 2 (2010): 37-38.