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Features of liver damage progression in insulin resistant patients

Journal «MEDICINA» № 1, 2017, pp.99-107 (Research)

Authors

Roytberg G. E.
Academician of the Russian Academy of Sciences, Chief of the Department of Therapy and Family Medicine, Russian National Research Medical University, President of JSC «Medicina»

Sharkhun O. O.
PhD, Associate Professor, Department of Therapy and Family Medicine, Russian National Research Medical University, internist in JSC «Medicina»

Corresponding author

Sharkhun O. O., e-mail: olga_sharkhun@mail.ru

Abstract

The article assesses the state of the liver in patients with nonalcoholic fatty liver disease (NAFLD) after 5 years of follow up. We tried to identify the progression features of the pathological process in the liver in insulin resistant patients. NAFLD is considered in close association with the metabolic syndrome, based on insulin resistance (IR) phenomenon. We presented clinical outcomes of NAFLD within 5 years in patients with and without IR, as well as the development of IR in NAFLD patients. Among patients with NAFLD within 5 years of follow up we estimated steatosis to steatohepatitis transformation, as well as the degree of steatohepatitis activity on clinical and laboratory data.

Key words

fatty liver, steatohepatitis, insulin resistance, risk factors, abdominal obesity, questionnaires, patient physical activity

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