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Modern understanding of the physiological and therapeutic and prophylactic effects of actions hypoxia and hypercapnia

Journal «MEDICINA» ¹ 3, 2016, pp.45-68 (Reviews)

Authors

Gridin L. A.
Doctor of Medicine, Professor, honored doctor of Russia, winner of Russian Government Prize in Science and Technology, head of manual therapy chair1

1 - I.M. Sechenov First Moscow State Medical University of the Russian Federation Ministry of Health

Abstract

Author presents modern views on the physiological and therapeutic and prophylactic effects of hypoxia and hypercapnia action. General conclusions are formulated concerning the human body adaptation to conditions of low partial pressure of oxygen in the alveolar air, according to which specific adaptation component is a series of structural and functional changes aimed at improving the oxygen tissue supply, and non-specific adaptation of the component is to activate the mechanisms of cellular and humoral immunity, detoxification cytochrome P-450, antioxidant systems. It is shown that the lack of scientific evidence on the comparative effectiveness of these potentially promising methods to optimize the state of representatives of the various socio-professional groups, the timing of the application and its duration determines the relevance of applied research of physiological and therapeutic and prophylactic effects of hypoxia and hypercapnia.

Key words

hypoxia, hypercapnia, hypoxia physiological effects, physiological effects of hypercapnia, hypoxia, therapeutic and preventive effects, the therapeutic and prophylactic effects of hypercapnia

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