Cognitive Factors of Remission in Alcohol Dependence with Comorbid Depression (a narrative review)

Berezina A. A.¹
junior researcher;
ORCID: 0000-0002-5274-0137; SPIN: 9680-8178

Vyazova A. I.¹
junior researcher;
ORCID: 0000-0003-2394-2720; SPIN: 7970-8910

Goncharov O. V.¹
Cand. Sci. (Med.);
ORCID: 0000-0003-2110-5525; SPIN: 4432-6110

Klimanova S. G.¹
researcher;
ORCID: 0000-0001-6162-1511; SPIN: 5316-3445

Krupitsky E. M.¹³
Dr. Sci. (Med.), Deputy Director for Scientific Work, Associate Professor, Head of the Department of Narcology; Director of the A.V. Waldman Institute of Pharmacology;
ORCID: 0000-0002-0529-4525; SPIN: 8796-5526

Trusova A. V.¹²
Cand. Sci. (Psych.);
ORCID: 0000-0002-0921-4203; SPIN: 3486-9970

Rybakova K. V.¹
Dr. Sci. (Med.), Head of the therapy department for inpatient patients with addictive disorder;
ORCID: 0000-0003-1797-1121; SPIN: 4511-2961

1V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of the Russian Federation, 3 Bekhtereva Street, Saint Petersburg 192019, Russia
2Saint Petersburg State University, Saint Petersburg, Russia
3Institute of Pharmacology named after A.V. Valdman, Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Anna A. Berezina; e-mail: aneta.berezina@gmail.com

The study had no sponsorship.

None declared.

02.04.2026

08.08.2026

Objective. To analyze the cognitive factors of remission in alcohol dependence with comorbid recurrent depression, with an emphasis on data from systematic reviews and meta-analyses. Methods. A narrative synthesis of data from randomized controlled trials, cohort and observational studies, systematic reviews, and meta-analyses published between 2000 and 2026. Searches were conducted in PubMed, Web of Science, Scopus. Results. The results of studies characterizing the degree and structure of cognitive deficits, as well as their psychological and neurophysiological mechanisms in the context of remission formation, are summarized. Conclusion. Promising directions for further research and the potential application of the obtained data in the development of individualized treatment are outlined.

alcohol dependence, comorbid depression, cognitive functioning, remission

10.29234/2308-9113-2026-14-3-88-102

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