Authors
Ponyakhina D. M.
5th year student1
Boyarshinov V. D.
Ph.D., Associate Professor of the Department of Pharmacology2
Gulyaev D. K.
Ph.D, Associate Professor of the Department of Pharmacognosy1
Burlutskaya A. A.
Junior Researcher at the Clinical Department of the Central Research Laboratory2
Belonogova V. D.
Doctor of Pharmacy, Head of the Department of Pharmacognosy1
1Perm State Pharmaceutical Academy, Russia, 614990, Perm, Polevaya str., 2
2Perm State Medical University named after Academician E.A. Wagner, Perm, Russia
Corresponding author
Dmitry Konstantinovich Gulyaev; e-mail: dkg2014@mail.ru
Financing
The study had no sponsorship.
Conflict of interests
The authors declare that there is no conflict of interest.
Abstract
Introduction. As a result of the aging of the population, age-related diseases are an urgent problem of modern medicine, the early manifestations of which include insulin resistance. To diagnose insulin resistance, one of the indirect methods is the glucose tolerance test (TSH). Since the use of oral hypoglycemic agents is limited due to the manifestation of clinically significant undesirable side effects, it is relevant to search for drugs among substances of plant origin that have a high safety profile. Plants of the genus Rubus (family Rosaceae) have antidiabetic potential, in particular Rubus idaeus, which has shown clinical efficacy in the treatment of gestational diabetes. The aim of the study is to study the sugar-lowering activity of an aqueous extract of raspberry rhizomes with roots in young and old animals. Materials and methods of research. A dry extract of rhizomes with raspberry roots (ECCM) was used as the object of the study. The raw materials for obtaining the extract were raspberry rhizomes with roots harvested in autumn. The assessment of the sugar-lowering activity of the studied extract was carried out by changing the concentration of glucose in the blood of intact animals and in TSH. The comparison drug was metformin. The results of the study and their discussion. When studying the effect of ECCM on the glycemia level of intact and experimental animals of different ages, the glucose concentration of the background observation period did not significantly differ from that of control animals of the same age, which indicates the absence of ECCM effect on blood glucose concentration. TSH revealed a statistically significant increase in blood glucose concentration in old rats compared with young ones, which indicates a change in carbohydrate metabolism. The administration of ECCM to young and old animals led to a statistically significant decrease in the hyperglycemic peak after 30 minutes compared with the control groups, after 60 and 120 minutes there were no significant differences with the control groups. Conclusion. The dried extract of raspberry rhizomes with roots does not affect the concentration of glucose in the blood of intact young and old rats, and in old animals it improves the indicators of glycemia in TSH. The extract of rhizomes with raspberry roots is promising for further study as an antidiabetic agent.
Key words
insulin resistance, raspberry, rhizomes with roots, extract, glucose tolerance test
DOI
References
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