The effect of health care associated risk factors on Streptococcus pneumoniae resistance to penicillin. Meta-analysis

Semenov S. A.¹

Khasanova G. R.²

1City Dental Clinic, Cheboksary
2Kazan state medical university, Kazan

Sergey A. Semenov; e-mail: sergejsemenov596@gmail.com

None declared.

The study had no sponsorship.

Relevance. To develop measures to combat the resistance of microorganisms to antibacterial drugs, it is important to investigate the factors associated with the development of antibiotic resistance. To conduct a systematic review and meta-analysis of studies on the association of individual factors associated with the provision of medical care with the development of diseases caused by penicillin-resistant (or insensitive) strains of Streptococcus pneumoniae. Methods. A literature search was conducted using the electronic databases PubMed, ScienceDirect, Google Scholar. The search depth is from January 1980 to December 2024. The studies were selected in English. The selection of articles and meta-analysis were carried out in accordance with the recommendations of the PRISMA Group and MOOSE. Conclusions. Previous administration of beta-lactam antibiotics for 1 or 3 months (OR=2.74, 95% CI 1.44-5.2, p=0.002, I2=0 and OR=2.12 (95%CI 1.62-2.78, p=0.001, I2=38%, respectively), hospitalization in the last six months (OR= 1.45, 95% CI 1.06-1.99, p=0.02, I2=19%), nosocomial infection (OR= 2.13, 95% CI 2.66-2.72, p=0.001, I2=22%), pneumonia suffered during the last year (OR= 1.85, 95% DI 1.29-2.66, p=0.001, I2=43%) were significant risk factors for the development of pneumococcal nonsusceptibility to penicillin. Significant risk factors for the development of pneumococcal resistance to penicillin are taking antibiotics in the last 3 months before the examination and hospitalization in the last six months (OR= 2.42, 95% CI 1.45-4.04, p=0.001, I2=79%).

antibiotic resistance, Streptococcus pneumoniae, pneumococcus, risk factors, penicillin resistance, penicillin susceptibility, penicillin

10.29234/2308-9113-2025-13-4-72-89

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