AboutContactsEditorial StaffEditorial CouncilArchiveFor AuthorsFor Reviewers

Use of Certain Calculated Hematological Parameters for the Diagnosis of Iron Deficiency Conditions in Children

Journal «MEDICINA» ¹ 2, 2024, pp.18-24 (Research)

Authors

Moshev A. V.
MD, Doctor of Clinical Laboratory Diagnostics1

Sychik E. V.
MD1

1 - Regional Consultative and Diagnostic Center, Rostov-on-Don, Russian Federation

Corresponding author

Moshev Anton Viktorovich; e-mail: kinger1@mail2000.ru

Funding

The study had no sponsorship.

Conflict of interest

None declared.

Abstract

Iron deficiency conditions have many dangerous consequences, especially in childhood. The purpose of the article is to assess the diagnostic significance of some new calculated hematological parameters (low hemoglobin density) in the diagnosis of abovementioned conditions. The study was carried out on biological material from patients undergoing examination at the Rostov-on-Don Regional Clinical and Diagnostic Centre using standard hematological, biochemical and immunological techniques. The results obtained indicate the high diagnostic value of the indicator.

Key words

iron deficiency conditions, low hemoglobin density

DOI

References

1. Vorobyov P.A. Anemicheskij sindrom v klinicheskoj praktike. [Anemic syndrome in clinical practice.] Moscow: N'yudiamed. 2001. (In Russ.)

2. Balashova E.A., Shadrina I.L., Pogodina A.A. Vliyanie deficita zheleza na pamyat' i vnimanie mal'chikov-podrostkov. [The effect of iron deficiency on memory and attention in adolescent boys.] Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education] 2022; (3): 112. (In Russ.)

3. Smirnova L.A. Deficit zheleza: biologiya, kriterii diagnoza, effektivnost' terapii. [Iron deficiency: biology, diagnostic criteria, effectiveness of therapy.] Medicinskie novosti [Medical news] 2013; (5): 16-20. (In Russ.)

4. Strutynsky A.V. Zhelezodeficitnye anemii. Diagnostika i lechenie. [Iron deficiency anemia. Diagnosis and treatment.] Trudnyj pacient [Difficult patient] 2013; 11(12): 38-43. (In Russ.)

5. Samorodnova E.A. Zhelezodeficitnye sostoyaniya u detej: sovremennye aspekty problemy, vozmozhnosti pervichnoj profilaktiki. [Iron deficiency conditions in children: modern aspects of the problem, possibilities of primary prevention.] Pediatriya. Consilium Medicum [Pediatrics. Consilium Medicum] 2022; (4): 302-308, doi: 10.26442/26586630.2022.4.201960 (In Russ.)

6. Klinicheskie rekomendacii «Zhelezodeficitnaya anemiya», vozrastnaya kategoriya: vzroslye, deti, utverzhdeny Minzdravom RF 8.09.2021. [Clinical recommendations «Iron deficiency anemia», age category: adults, children, approved by the Ministry of Health of the Russian Federation on September 8, 2021.] Available at: https://cr.minzdrav.gov.ru/recomend/669­_1 (In Russ.)

7. Baranov I.I., Salnikova I.A., Nesterova L.A. Klinicheskie rekomendacii po diagnostike i lecheniyu zhelezodeficitnyh sostoyanij: vzglyad iz 2022 g. [Clinical guidelines for the diagnosis and treatment of iron deficiency conditions: a view from year 2022.] Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and gynecology: news, opinions, training] 2022; 10(2): 56-64, doi: 10.33029/2303-9698-2022-10-2-56-64. (In Russ.)

8. Sanakoeva L.P. Laboratornaya diagnostika zhelezodeficitnoj anemii u podrostkov aktual'nye voprosy pediatrii. [Laboratory diagnosis of iron deficiency anemia in adolescents – current issues in pediatrics.] Materialy nauchno-prakticheskoj kraevoj konferencii s mezhdunarodnym uchastiem, posvyashchennoj 95-letiyu Gorodskoj detskoj klinicheskoj bol'nicy ¹ 3. [Materials of the scientific and practical regional conference with international participation, dedicated to the 95th anniversary of the City Children's Clinical Hospital No. 3.] Permskij nacional'nyj issledovatel'skij politekhnicheskij universitet [Perm National Research Polytechnic University.] Perm, 2018. P.178-181. (In Russ.)

9. Arija, V., Hernández-Martínez C., Tous M., Canals J., Guxens M., Fernández-Barrés S., Ibarluzea J., Babarro I., SolerBlasco R., Llop S., Vioque J., Sunyer J., Julvez J., Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study. Nutrients 2019; 11(12): 2999.

10. Weimann A., Cremer M., Hernáiz-Driever P., Zimmermann M. Delta-He, Ret-He and a new diagnostic plot for differential diagnosis and therapy monitoring of patients suffering from various disease-specific types of anemia. Clin Lab. 2016; 62(4): 667-677, doi: 10.7754/clin.lab.2015.150830

11. Youssef M.A.M., Hassan E.S., Yasien D.G. Effect of iron deficiency anemia on language development in preschool Egyptian children. Int. J. Pediatr Otorhinolaryngol. 2020; 135: 110114, doi: 10.1016/j.ijporl.2020.110114

12. Schoorl M., Schoorl M., Linssen J., et al. Efficacy of advanced discriminating algorithms for screening on iron-deficiency anemia and β-thalassemia trait: A multicenter evaluation. Am J Clin Pathol. 2012; 138(2): 300-304, doi: 10.1309/AJCP20UTTCAYKUDX

13. Urrechaga E. The new mature red cell parameter, low haemoglobin density of the Beckman-Coulter LH750: clinical utility in the diagnosis of iron deficiency. Int. Jnl. Lab. Hem. 2010; 32(1 Pt 1): e144-e150.

14. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: World Health Organization, 2020. Available at: https://www.who.int/publicationsMtem/9789240000124