Analysis of Blood Circulation Parameters of the Optic Nerve Head and Peripapillary Region of the Retina in Patients with Poag Against the Background of Post-COVID-19 Syndrome

Petrov S. Yu.
Doctor of Medicine, Head, Glaucoma Department, Ophthalmologist¹
ORCID 0000-0001-6922-0464-4314

Okhotsimskaya T. D.
MD, PhD, Ophthalmologist, Department of Retinal and Optic Nerve Pathology¹
ORCID 0000-0003-1121-4314

Markelova O. I.
Postgraduate, Glaucoma Department¹
ORCID 0000-0002-8090-6034

1 - Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia

Markelova O.I.; e-mail: levinaoi@mail.ru

None declared.

The study had no sponsorship.

Laser speckle flowgraphy (LSFG) is non-invasive method with high reproducibility determining the parameters of ocular blood flow. The purpose of this work is to study the blood circulation of the optic nerve head and the peripapillary region of the retina in patients with POAG against the background of post-COVID-19 syndrome using LSFG. Material and methods. The study included 40 patients with advanced stage POAG who had COVID-19 within the previous 3 months, split into 2 subgroups depending on the severity of the disease (mild or moderate). The comparison group consisted of 20 individuals with an advanced stage of POAG who did not have COVID-19. Both groups were comparable in age, gender, general condition, systemic and previous eye diseases. Optic nerve head blood flow was measured using the LSFG-NAVI device (Japan), pulse wave indicators (Skew, BOS, BOT, RR, FR, FAI, ATI and RI) tissue and vascular areas were assessed using LSFG Analyzer software. Results. Reliably significant (p≤0.05) changes in pulse wave parameters were identified in patients of the 2nd subgroup – advanced stage of POAG, post-COVID-19 syndrome after moderate COVID-19. For the microvasculature of the optic nerve head and the peripapillary retina, significant (p≤0.05) changes were revealed in most of the studied pulse wave parameters in patients of the 2nd subgroup; indicators BOT, BOS and FAI decreased, and Skew and RI increased, changes in these indicators were 12%, 8%, 10% and 13%, 13%, respectively. Conclusion. Quantitative and qualitative assessment of the microcirculation of the optic nerve head and the peripapillary region of the retina can be carried out using the modern LSFG method, which allows for rapid analysis of the parameters of the pulse wave of the hemodynamics of the eye, as well as identification of vascular disorders.

post-COVID-19 syndrome, primary open-angle glaucoma, ocular blood flow, LSFG, pulse wave indicators

10.29234/2308-9113-2024-12-1-1-10

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