Assessment of the Effect of Clinical Aspects of the Course of Combined Pathology (HIV Infection and Tuberculosis) on the Spread of Mycobacteria of Tuberculosis in Foci, as One of the Main Risk Factors for Infection

Asmanova M. A.
Lecturer, Chair for Epidemiology, Microbiology and Virology¹

Lukyanenko N. V.
Doctor of Medicine, Professor, Chair for Epidemiology, Microbiology and Virology¹

1 - Altai State Medical University, Barnaul, Russia

Asmanova Maria; e-mail: latmaria@mail.ru

The study had no sponsorship.

None declared.

Introduction: The article presents an analysis of the state of the immune system of HIV-infected patients with tuberculosis, the rate of recurrence of tuberculosis in HIV-infected people against the background of insufficient preventive therapy against HIV-infection and tuberculosis. Aim: To assess the effect of clinical aspects of the course of combined pathology (HIV infection and tuberculosis) on the spread of isolation of bacteria of tuberculosis mycobacteria as one of the main risk factors for infection in foci. Materials and methods: comparative analysis of isolation of bacteria of tuberculosis mycobacteria among patients with combined pathology (tuberculosis and HIV) was carried out (main group): determination of CD4 lymphocyte cell number and isolation of tuberculosis mycobacteria (n = 100). The number of TB recurrences in the main group (100 patients) and comparison group (TB patients) – 100 patients were studied. Data processing was carried out using the calculation of intensive and extensive indicators, the calculation of the standard error of the average (m). Statistical analysis was performed using Microsoft Excel. The results testified: the impact of the clinical course in tuberculosis patients with HIV infection characterized by an immunodeficiency condition, the presence of stages of 4B and 4V HIV infection (65,0 (95% RI:55;74)) and the recurrent course of tuberculosis in 25% (95% RI:17,5;34) is 1.4 times higher than in tuberculosis and is one of the main risk factors for infection in foci.

tuberculosis, HIV-infection, combined pathology, isolation of bacteria

10.29234/2308-9113-2021-9-4-40-47

1. Tsybikova E.B., Punga V.V., Rusakova L.I. Tuberkulez, sochetannyy s VICh-infektsiey, v Rossii: statistika i vzaimosvyazi. [Tuberculosis, combined with HIV infection, in Russia: statistics and interconnections.] Tuberkulez i bolezni legkikh [Tuberculosis and lung disease] 2018; (12): 9-17. (In Russ.)

2. Nechaeva O.B. Epidemicheskaya situatsiya po tuberkulezu v Rossii. [Tuberculosis epidemic in Russia.] Tuberkulez i bolezni legkikh [Tuberculosis and lung disease] 2018; 96 (8): 15-24. doi: 10.21292/2075-1230-2018-96-8-15-24 (In Russ.)

3. Frolova O.P. Profilaktika tuberkuleza u bol'nykh VICh-infektsiey. Metodicheskie rekomendatsii. [Prevention of tuberculosis in patients with HIV infection. Methodological recommendations.] Moscow: GBOU VPO RNIMU im. N.I. Pirogova Minzdrava Rossii, 2014. 36 p. (In Russ.)

4. Snider D.E., Рoper W.L. The new tuberculosis. New Engl.J Med 1992; (10): 703-5. doi: 10.21292/2075-1230-2018-96-8-15-24

5. Punga V.V., Tsybikova E.B., Yakimova M.A., Izmaylova T.V. Rezul'taty lecheniya bol'nykh tuberkulezom, sochetannym s VICh-infektsiey. [Outcomes of TB patients combined with HIV infection.] Sotsial'nye aspekty zdorov'ya naseleniya [Social aspects of public health] 2017; (53): 12. (In Russ.)

6. Belyakova N.V., Frolova O.P., Zolotareva L.V., Novoselova O.A. Analiz sostoyaniya zabolevaemosti tuberkulezom sredi bol'nykh VICh-infektsiey (na primere pyati oblastey Tsentral'nogo federal'nogo okruga). [Analysis of tuberculosis incidence among patients with HIV infection (using the example of five regions of the Central Federal District).] Epidemiologiya i Vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis] 2010; (5): 54-59. (In Russ.)

7. Ravil'one M.K., Korobitsyn A.A. Likvidatsiya tuberkuleza – novaya strategiya VOZ v eru tseley ustoychivogo razvitiya, vklad Rossiyskoy Federatsii. [The elimination of tuberculosis is a new strategy of WHO in the era of sustainable development goals, the contribution of the Russian Federation.] Tuberkulez i bolezni legkikh [Tuberculosis and lung disease] 2016;(11):7-15. doi: 10.21292/2075-1230-2016-94-11-7-15 (In Russ.)